Ischemia as a factor affecting innate immune responses in kidney transplantation.
Ischemia as a factor affecting innate immune responses in kidney transplantation.
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DOI：
10.1097/mnh.0000000000000190
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发表时间：
2016-01
影响因子：
3.2
通讯作者：
McKay DB
中科院分区：
文献类型：
--
作者：
Kasimsetty SG;McKay DB
在移植器官获取过程中不可避免地会发生缺血性损伤，再灌注后的炎症会加重缺血性损伤。这篇综述的目的是描述先天性免疫系统在移植肾缺血诱导肾损伤中的作用。模式识别受体在缺血免疫反应中的关键作用被描述。先天免疫受体是改善供肾缺血性损伤的新靶点。几个模式识别受体家族是肾脏获取过程中早期损伤事件的直接介质，也是移植后的先天和适应性免疫反应。与供体肾脏先天免疫系统激活相关的有害事件显著影响同种异体移植的短期和长期结果。虽然已经提出了许多治疗方法来减少缺血性供体肾损伤，但靶向先天免疫系统是一个令人兴奋的新领域，正在获得移植的重大兴趣。随着我们更多地了解这些重要的受体是如何被缺血调节的，策略可能会发展到允许它们在缺血性肾损伤中的调节。
Ischemic injury inevitably occurs during the procurement of organs for transplantation and the injury is worsened by inflammation following reperfusion. The purpose of this review is to describe the role of the innate immune system in ischemia-induced renal injury in kidneys procured for transplantation. The key role of pattern recognition receptors in immune responses to ischemia is described. Innate immune receptors are emerging novel targets for amelioration of ischemic injury of donor kidneys. Several families of pattern recognition receptors are direct mediators of early injurious events during kidney procurement, and also innate and adaptive immune responses after transplantation. The deleterious events associated with activation of the innate immune system in donor kidneys significantly contributes to short and long-term allograft outcomes. Although a number of therapies have been proposed to decrease ischemic donor kidney injury, targeting the innate immune system is an exciting new area that is gaining significant interest in transplantation. As we learn more about how these important receptors are regulated by ischemia, strategies will likely evolve to allow their modulation in ischemic renal injury.