Future aspects of bioprocess monitoring
Future aspects of bioprocess monitoring
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DOI：
10.1007/10_2006_036
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Ulber, Roland
中科院分区：
文献类型：
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作者：
Becker, Thomas;Hitzmann, Bernd;Ulber, Roland
大自然有着令人印象深刻的能力，通过应用高度进化的原理，使用最小的空间和相对简单的构建模块，有效而精确地控制生物过程。目前的挑战是将这些原理转化为技术上适用的精确分析系统，可用于许多应用。本文综述了传感器技术和控制策略在不同生物过程如发酵、生物转化和下游过程中的一些新方法。它侧重于生物和化学传感器，光学传感器，DNA和蛋白质芯片技术，软件传感器，以及用于改进过程监测和控制的数据评估的现代方面。
Nature has the impressive ability to efficiently and precisely control biological processes by applying highly evolved principles and using minimal space and relatively simple building blocks. The challenge is to transfer these principles into technically applicable and precise analytical systems that can be used for many applications. This article summarizes some of the new approaches in sensor technology and control strategies for different bioprocesses such as fermentations, biotransformations, and downstream processes. It focuses on bio- and chemosensors, optical sensors, DNA and protein chip technology, software sensors, and modern aspects of data evaluation for improved process monitoring and control.