Kinetics of Human C-peptide in Man
Kinetics of Human C-peptide in Man
复制标题
人类 C 肽在人体中的动力学
作者：
O. Faber;H. Kehlet;S. Madsbad;C. Binder
有关人体C肽代谢的研究综述表明，肾脏是C肽清除的主要器官。C肽的周转率与胰岛素原相似，但比胰岛素慢得多。使用口服葡萄糖或静脉内胰高血糖素给药后正常受试者中相应C肽和胰岛素浓度的分析来定义两种肽之间的关系。这些结果表明，不同的外周静脉胰岛素浓度可能对应于相同的C肽浓度，这取决于采样条件。
A review of studies concerned with the metabolism of human C-peptide showed that the kidney is the major organ in C-peptide removal. The turnover rate of C-peptide was similar to that of proinsulin but considerably slower than that of insulin. An analysis of corresponding C-peptide and insulin concentrations in normal subjects after the administration of oral glucose or intravenous glucagon was used to define the relationships between the two peptides. These results show that different peripheral vein concentrations of insulin may correspond to identical C-peptide concentrations, depending on sampling conditions.