Maintenance of High-Energy Brain Phosphorous Compounds During Insulin-Induced Hypoglycemia in Men: 31P Nuclear Magnetic Resonance Spectroscopy Study
Maintenance of High-Energy Brain Phosphorous Compounds During Insulin-Induced Hypoglycemia in Men: 31P Nuclear Magnetic Resonance Spectroscopy Study
复制标题
男性胰岛素引起的低血糖期间高能脑磷化合物的维持：31P 核磁共振波谱研究
作者：
J. Hilsted;K. Jensen;C. Thomsen;S. Larsen;O. Henriksen
31P核磁共振(31P)谱可以对人类大脑中富含能量的磷化合物进行非侵入性研究。为探讨胰岛素诱导低血糖时外周血糖浓度与全脑磷酸盐代谢的关系，对6名男性静脉注射胰岛素(0.15IU/kg体重)前后的31P核磁共振波谱进行了研究。与降糖前相比，脑内PI、糖磷酸盐、磷酸肌酸、磷酸二酯和三磷酸腺苷的含量没有明显变化，脑pH在实验过程中保持不变。这些结果表明，富含能量的磷化合物的大脑整体轮廓不受实验性胰岛素诱导的人类低血糖的影响。
31P nuclear magnetic resonance (NMR) spectroscopy allows noninvasive studies of cerebral energy-rich phosphorous compounds in humans. In an attempt to characterize the relationship between peripheral blood glucose concentrations and whole-brain phosphate metabolism during insulin-induced hypoglycemia, 31P NMR spectra were obtained before and after intravenous injection of insulin (0.15 IU/kg body wt) in six men. Compared with prehypoglycemic measurements, no significant changes were found in brain content of Pi, sugar phosphates, phosphocreatine, phosphodiesters, and ATP, and brain pH remained constant during the experiment. These results show that the integrated brain profile of energy-rich phosphorous compounds is unaffected by experimental insulin-induced hypoglycemia in humans.