Circular RNAs in Vascular Functions and Diseases
Circular RNAs in Vascular Functions and Diseases
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DOI：
10.1007/978-981-13-1426-1_23
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Zhong, Chongjun
中科院分区：
文献类型：
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作者：
Ding, Shengguang;Zhu, Yujiao;Zhong, Chongjun
血管疾病是五大死亡原因之一，并影响各种其他疾病，如心脏，神经系统和代谢紊乱。血管功能障碍是缺血、癌症和炎性疾病的标志，并且可以加速疾病的进展。环状RNA（Circular RNA，circRNA）是一类具有共价键环结构的非编码RNA，在多种疾病中表达异常。circRNA通过海绵状的microRNA（miRNAs）调节基因表达，也可用作疾病生物标志物。本文就circRNA在血管疾病中的作用进行综述，包括血管功能障碍、动脉粥样硬化、糖尿病相关视网膜血管功能障碍、慢性血栓栓塞性肺动脉高压、颈动脉粥样硬化性疾病、肝细胞癌肝血管浸润、主动脉瘤、冠状动脉疾病和2型糖尿病。
Vascular disease is one of the top five causes of death and affects a variety of other diseases, such as heart, nervous system, and metabolic disorders. Vascular dysfunction is a hallmark of ischemia, cancer, and inflammatory diseases and can accelerate the progression of diseases. Circular RNAs (circRNAs) are a new type of noncoding RNAs with covalent bond ring structure, which have been reported to be abnormally expressed in many human diseases. circRNAs regulate gene expression through the sponging of microRNAs (miRNAs) and can also be used as disease biomarkers. Here we will summarize the functions of circRNAs in vascular diseases, including vascular dysfunction, atherosclerosis, diabetes mellitus-related retinal vascular dysfunction, chronic thromboembolic pulmonary hyper-tension, carotid atherosclerotic disease, hepatic vascular invasion in hepatocellular carcinoma, aortic aneurysm, coronary artery disease, and type 2 diabetes mellitus.