A multi-center cross-sectional study of 1495 Chinese oral lichen planus patients.
A multi-center cross-sectional study of 1495 Chinese oral lichen planus patients.
复制标题
DOI：
10.1111/odi.14798
复制
发表时间：
2023-11
期刊：
影响因子：
3.8
通讯作者：
Jiaxin Liu;Hao Xu;G. Tang;Hongwei Liu;Zheng Sun;Gang Zhou;Bin Cheng;Wenmei Wang;Hong He;Bin Guo;Wenxia Meng;Qing Liu;Jiongke Wang;Xiaobo Luo;Yu Zhou;Lu Jiang;Xin Zeng;H. Dan;Qianming Chen
中科院分区：
文献类型：
--
作者：
Jiaxin Liu;Hao Xu;G. Tang;Hongwei Liu;Zheng Sun;Gang Zhou;Bin Cheng;Wenmei Wang;Hong He;Bin Guo;Wenxia Meng;Qing Liu;Jiongke Wang;Xiaobo Luo;Yu Zhou;Lu Jiang;Xin Zeng;H. Dan;Qianming Chen
目的探讨口腔扁平苔藓（OLP）的临床流行病学特征及糜烂/溃疡型OLP的危险因素。材料与方法本研究纳入了来自11家不同医院的OLP患者。采用描述性统计方法分析OLP的临床流行病学特征，采用Logistic回归、敏感性分析和亚组分析方法分析OLP的危险因素。结果患者平均年龄为49.2 ± 13.3岁，女性占61.4%。网状、充血/肿胀和糜烂/溃疡病变的患者比例分别为47.9%、27.8%和24.2%。糜烂性/溃疡性OLP的风险因素分析确定了以下变量：年龄、12个月或以上的病程、II°-III°牙结石、高血压、糖尿病和心脏病以及居住地区。亚组分析显示，在有和无危险行为的患者中，糜烂性/溃疡性OLP的危险因素存在显著差异。结论本研究中国人群OLP患者的临床流行病学特征与发达国家的现有报道基本一致。通过临床流行病学分析，我们确定了与糜烂/溃疡型OLP相关的临床特征。
OBJECTIVE To explore the clinical epidemiological characteristics of oral lichen planus (OLP) and risk factors for erosive/ulcerative OLP. MATERIALS AND METHODS Patients diagnosed with OLP from 11 different hospitals were included in the study. Descriptive statistical methods were used to explore the clinical epidemiological characteristics and logistic regression, sensitivity analysis, and subgroup analysis were utilized to explore the risk factors for erosive/ulcerative OLP. RESULTS The average age of patients was 49.2 ± 13.3 years, and 61.4% of the patients were women. The ratios of patients with reticular, hyperemic/erythematous, and erosive/ulcerative lesions were 47.9%, 27.8%, and 24.2%, respectively. Analysis of risk factors for erosive/ulcerative OLP identified the following variables: age, course of disease of 12 months or more, II°-III° dental calculus, hypertension, diabetes, and heart disease, as well as regions of habitation. Subgroup analysis showed significant differences in risk factors for erosive/ulcerative OLP in patients with and without risk behaviors. CONCLUSION The clinical epidemiological characteristics of patients with OLP in the Chinese population in this study are basically consistent with existing reports in developed countries. And we identified clinical characteristics associated with erosive/ulcerative OLP through clinical epidemiological analysis.