Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse.
Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse.
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DOI：
10.1016/j.biopsych.2022.01.019
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发表时间：
2022-06-15
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
阿片类药物滥用被假设为损害调节负面情绪的能力，如通过内脏和外周生理信号所表现的。然而，阿片类药物滥用中自上而下的认知情绪调节的神经生理学损害以前没有被证明。服用阿片类药物90天或更长时间的慢性疼痛患者（N=149;女性n=98）接受了脑电图（EEG）负性情绪调节任务。参与者被指示查看或重新评价3秒的负面图像。使用当前阿片类药物滥用测量的有效截止评分，将参与者分类为表现出与阿片类药物滥用一致的异常药物相关行为（MISUSE+）或阿片类药物滥用的低风险（MISUSE-）。参与者报告了他们在过去一周内对阿片类药物的渴望以及对负面情绪的渴望。我们观察到X组条件相互作用（p=0.003），因此，在重新评估期间，误用-组降低了EEG的晚期正电位（LPP），而误用+组在重新评估期间显示LPP增加。在控制了一系列潜在的混杂变量（包括阿片类药物剂量、疼痛和抑郁）后，这种负面情绪调节的缺陷仍然显著。在重新评估期间LPP升高与更严重的阿片类药物渴望相关。阿片类药物滥用会导致情绪调节自上而下的缺陷，这种缺陷早在负面刺激出现后400毫秒就开始了。目前尚不清楚情绪失调是否是阿片类药物滥用的原因、相关因素或后果。尽管如此，针对阿片类药物滥用中的情绪失调进行重新评估为重点的干预可能是一种重要的治疗方法。
Opioid misuse is hypothesized to compromise the ability to regulate negative emotions, as manifested through visceral and peripheral physiological signals. However, neurophysiological impairment of top-down cognitive emotion regulation in opioid misuse has not previously been shown. Patients with chronic pain who had been taking opioids for 90 days or longer (N=149; Female n=98) underwent a negative emotion regulation task with electroencephalography (EEG). Participants were instructed to view or reappraise negative images presented for 3 s. Using a validated cutoff score on the Current Opioid Misuse Measure, participants were classified as exhibiting aberrant drug-related behavior consistent with opioid misuse (MISUSE+) or as being low risk for opioid misuse (MISUSE-). Participants reported their general opioid craving in the past week and craving in response to negative emotions. We observed a group X condition interaction (p=0.003), such that the MISUSE- group decreased the late positive potential (LPP) of the EEG during reappraisal whereas the MISUSE+ group showed increased LPP during reappraisal. This deficit in negative emotion regulation remained significant after controlling for an array of potential confounding variables, including opioid dose, pain, and depression. Heightened LPP during reappraisal was associated with more severe opioid craving. Opioid misuse can occasion top-down deficits in emotional regulation that begin as early as 400 milliseconds after presentation of negative stimuli. It remains unknown whether emotion dysregulation is the cause, correlate, or consequence of opioid misuse. Nonetheless, targeting emotion dysregulation in opioid misuse with reappraisal-focused interventions may represent an important treatment approach.
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DOI：
10.1016/j.jpain.2008.10.008
发表时间：
2009-02
期刊：
The journal of pain
影响因子：
--
作者：
Chou R;Fanciullo GJ;Fine PG;Adler JA;Ballantyne JC;Davies P;Donovan MI;Fishbain DA;Foley KM;Fudin J;Gilson AM;Kelter A;Mauskop A;O'Connor PG;Passik SD;Pasternak GW;Portenoy RK;Rich BA;Roberts RG;Todd KH;Miaskowski C;American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
通讯作者：
American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
影响因子：
25.8
作者：
Froeliger B;McConnell PA;Bell S;Sweitzer M;Kozink RV;Eichberg C;Hallyburton M;Kaiser N;Gray KM;McClernon FJ
通讯作者：
McClernon FJ
影响因子：
5.9
作者：
Garland, Eric L.;Hanley, Adam W.;Howard, Matthew O.
通讯作者：
Howard, Matthew O.
影响因子：
2.6
作者：
Cuthbert, BN;Schupp, HT;Lang, PJ
通讯作者：
Lang, PJ
影响因子：
39
作者：
Garland EL;Hanley AW;Nakamura Y;Barrett JW;Baker AK;Reese SE;Riquino MR;Froeliger B;Donaldson GW
通讯作者：
Donaldson GW