Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction
Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction
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DOI：
10.1203/01.pdr.0000128983.54614.7e
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发表时间：
2004-07-01
影响因子：
3.6
通讯作者：
Hüppi, PS
中科院分区：
文献类型：
--
作者：
Tolsa, CB;Zimine, S;Hüppi, PS
胎盘功能不全伴胎儿宫内生长受限（IUGR）是围产期死亡和发病的重要原因，并随后与认知功能、注意力和学习表现方面的显著神经发育障碍相关。这种关联的潜在生物学原因尚不清楚。通过早期和足月磁共振成像（MRI）研究了28例早产儿（胎龄32.5 +/- 1.9周）。使用先进的定量体积三维MRI技术测量了14名患有胎盘功能不全的早产儿的脑组织体积，胎盘功能不全的定义为产前多普勒测量结果异常和平均出生体重
Placental insufficiency with fetal intrauterine growth restriction (IUGR) is an important cause of perinatal mortality and morbidity and is subsequently associated with significant neurodevelopmental impairment in cognitive function, attention capacity, and school performance. The underlying biologic cause for this association is unclear. Twenty-eight preterm infants (gestational age 32.5 +/- 1.9 wk) were studied by early and term magnetic resonance imaging (MRI). An advanced quantitative volumetric three-dimensional MRI technique was used to measure brain tissue volumes in 14 premature infants with placental insufficiency, defined by abnormal antenatal Doppler measurements and mean birth weights