A common biological basis of obesity and nicotine addiction
A common biological basis of obesity and nicotine addiction
复制标题
DOI：
10.1038/tp.2013.81
复制
发表时间：
2013-10-01
影响因子：
6.8
通讯作者：
Stefansson, K.
中科院分区：
文献类型：
--
作者：
Thorgeirsson, T. E.;Gudbjartsson, D. F.;Stefansson, K.
吸烟会影响体重，吸烟者的体重低于非吸烟者，戒烟往往会导致体重增加。尼古丁对食欲和新陈代谢的影响部分解释了体重和吸烟之间的关系。然而，大脑奖励系统参与控制食物和烟草的摄入。我们评估了单核苷酸多态性（SNPs）影响体重指数（BMI）对吸烟行为的影响，并在冰岛样本（N = 34 216名吸烟者）中对与两种吸烟表型（吸烟开始（SI）和每天吸烟数量（CPD））相关的荟萃分析中确定的32个SNPs进行了测试。根据其对BMI的影响，SNPs与SI（r = 0.019，P = 0.00054）和CPD（r = 0.032，P = 8.0 × 10（-7））相关。这些发现在第二个大型数据集（N = 127 274，其中76 242名吸烟者）中重复，包括SI（P = 1.2 x 10（-5））和CPD（P = 9.3 x 10（-5））。值得注意的是，与BMI最密切相关的变异（FTO中的rs 1558902-A）与吸烟行为无关。与吸烟行为的关联不是由于SNP对BMI的影响。我们的研究结果有力地指出了一个共同的生物学基础，调节我们对烟草和食物的食欲，从而使尼古丁成瘾和肥胖变得脆弱。
Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N = 34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r = 0.019, P = 0.00054) and CPD (r = 0.032, P = 8.0 x 10(-7)). These findings replicate in a second large data set (N = 127 274, thereof 76 242 smokers) for both SI (P = 1.2 x 10(-5)) and CPD (P = 9.3 x 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.