Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly.
Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly.
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DOI：
10.1016/j.biomaterials.2016.07.011
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发表时间：
2016-10
期刊：
影响因子：
14
通讯作者：
Yaobin Wu;Ling Wang;Xin Zhao;Sen Hou;Baolin Guo;P. Ma
中科院分区：
文献类型：
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作者：
Yaobin Wu;Ling Wang;Xin Zhao;Sen Hou;Baolin Guo;P. Ma
传统生物材料，如热固性弹性体，由于缺乏对生物刺激的响应性和难以纳入生物功能，模拟自然功能动力学是有限的。此外，传统热固性弹性体由于共价键的不可逆断裂而导致的机械断裂将导致其永久性能的丧失。为了克服这些挑战，可降解的自愈合超分子生物弹性体被设计成由弹性的聚庚二酸甘油(PGS)主链和多个氢键缩脲基嘧啶酮(UPY)接枝而成。由于动态的超分子相互作用，这些超分子弹性聚合物表现出高效的自我修复、快速的形状记忆能力和高度可调的力学性能，在体外表现出良好的生物相容性，在体内表现出温和的宿主反应。通过组合模块化方法，这些超分子生物弹性体被进一步组装成一个多功能平台，以扩大它们在不同生物医学领域的应用。其中包括具有形状记忆能力和各向异性机械性能的复杂3D支架，通过逐层技术控制的药物输送模式，通过物理修饰的表面抗菌复合材料，以及通过将不同的细胞负载的自愈膜结合在一起的空间定向细胞共培养系统，展示了它们在需要动态特性和生物功能的广泛生物医学应用中的潜力。
Mimicking native functional dynamics for traditional biomaterials such as thermoset elastomers is limited due to their lack of responsiveness to biological stimuli and difficulties to incorporate biofunctionalities. Furthermore, the mechanical fracture of traditional thermoset elastomers caused by irreversible covalent bond rupture would lead to their permanent loss of properties. To overcome these challenges, degradable self-healed supramolecular bioelastomers are designed by an elastic poly(glycerol sebacate) (PGS) backbone and multiple hydrogen-bonding ureido-pyrimidinone (UPy) grafts. These supramolecular elastic polymers exhibit efficient self-healing, rapid shape-memory abilities and highly tunable mechanical properties due to the dynamic supramolecular interactions, and perform a good biocompatibilityin vitroand a mild host responsein vivo. By combining modular approaches, these supramolecular bioelastomers have been further assembled into a multifunctional platform to expand their applications in different biomedical fields. These include a complex 3D scaffold with shape-memory capacity and anisotropic mechanical properties, a controllable drug delivery modelviaa layer-by-layer technique, a surface antibacterial composite by physical modification, and a spatial oriented cell co-culture systemviaincorporating different cell-laden self-healing films, demonstrating their potential as building blocks in a wide range of biomedical applications where dynamic properties and biological functions are desired.