The Tohoku Medical Megabank Project: Design and Mission.
The Tohoku Medical Megabank Project: Design and Mission.
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DOI：
10.2188/jea.je20150268
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发表时间：
2016-09-05
影响因子：
4.7
通讯作者：
Yamamoto M
中科院分区：
文献类型：
--
作者：
Kuriyama S;Yaegashi N;Nagami F;Arai T;Kawaguchi Y;Osumi N;Sakaida M;Suzuki Y;Nakayama K;Hashizume H;Tamiya G;Kawame H;Suzuki K;Hozawa A;Nakaya N;Kikuya M;Metoki H;Tsuji I;Fuse N;Kiyomoto H;Sugawara J;Tsuboi A;Egawa S;Ito K;Chida K;Ishii T;Tomita H;Taki Y;Minegishi N;Ishii N;Yasuda J;Igarashi K;Shimizu R;Nagasaki M;Koshiba S;Kinoshita K;Ogishima S;Takai-Igarashi T;Tominaga T;Tanabe O;Ohuchi N;Shimosegawa T;Kure S;Tanaka H;Ito S;Hitomi J;Tanno K;Nakamura M;Ogasawara K;Kobayashi S;Sakata K;Satoh M;Shimizu A;Sasaki M;Endo R;Sobue K;Tohoku Medical Megabank Project Study Group T;Yamamoto M
2011年3月11日的日本东部大地震(Geje)和随之而来的海啸给东北地区的太平洋海岸造成了毁灭性的破坏。由东北大学东北医科大学(ToMMO)和岩手县医科大学岩手县医科大学组织(IMM)共同实施的东北医科大学医科巨库项目(TMM)已经启动，以实现创造性的重建并解决这场灾难后的医疗问题。我们在宫城县和岩手县启动了两项前瞻性队列研究：一项以人口为基础的成人队列研究，TMM社区队列研究(TMM CommCohort Study)，将招募80 000名参与者；以及一项出生和三代队列研究，TMM出生和三代队列研究(TMM BirThree Cohort Study)，将招募70 000名参与者，包括胎儿及其父母、兄弟姐妹、祖父母和大家庭成员。TMM CommCohort研究将在2013至2016年招募参与者，并对他们进行至少5年的跟踪调查。TMM BirThree队列研究将从2013年至2017年招募参与者，并对他们进行至少4年的跟踪调查。对于儿童，采用横断面设计的ToMMo儿童健康研究也于2012年11月在宫城县启动。将在两项前瞻性队列研究的基础上建立一个综合生物库，ToMMO和IMM将调查Geje的慢性医学影响。TMM的综合生物库由健康和临床信息、生物样本以及基因组和组学数据组成。该生物库旨在为个性化医疗和医疗奠定坚实的基础，主要针对这两个县因Geje而加重的疾病。生物库中的生物量和相关信息将分发给研究界。TMM本身也将承担基因组和组学研究。基因组研究的目标是：1)建立一个综合生物库；2)将基因组研究结果返回给队列研究的参与者，这将导致在不久的将来在受影响地区实施个性化医疗保健和医疗；以及3)为全球个性化医疗保健和医疗的发展做出贡献。通过TMM的活动，我们将阐明如何处理遭受大规模灾难破坏的地区的长期医疗问题，以及基因组信息对疾病预防的有用程度。
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.