The Validity of the 16-Item Version of the Prodromal Questionnaire (PQ-16) to Screen for Ultra High Risk of Developing Psychosis in the General Help-Seeking Population
The Validity of the 16-Item Version of the Prodromal Questionnaire (PQ-16) to Screen for Ultra High Risk of Developing Psychosis in the General Help-Seeking Population
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DOI：
10.1093/schbul/sbs068
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发表时间：
2012-11-01
影响因子：
6.6
通讯作者：
van der Gaag, Mark
中科院分区：
文献类型：
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作者：
Ising, Helga K.;Veling, Wim;van der Gaag, Mark
为了实现对精神病风险的常规筛查的实施，使用了前驱期问卷（PQ; Loewy等人，2005年）在一般求助人群中开发和测试。我们评估了一个连续的患者样本3533年轻人谁是寻求帮助的非精神病性障碍在二级精神卫生服务在海牙与PQ。我们进行了逻辑回归分析和CHi平方自动交互检测器决策树分析，以缩短原来的92个项目。受试者工作特征曲线被用来检查PQ-16的心理测量学特性。在一般求助人群中，PQ的16项版本上6个或更多个积极回答项目的截止分数产生了风险精神状态综合评估的正确分类（Yung等人，2005）精神病风险/临床精神病在44%的情况下，区分风险精神状态综合评估（CAARMS）诊断与无CAARMS诊断具有高灵敏度（87%）和特异性（87%）。这些结果与PQ-92相当。PQ-16是一个很好的自我报告筛选，用于二级精神卫生保健服务，以选择受试者进行精神病风险访谈。项目数量少，非常适合筛查大量求助人群，从而提高了在常规精神卫生服务中发现和治疗超高风险患者的可行性。
In order to bring about implementation of routine screening for psychosis risk, a brief version of the Prodromal Questionnaire (PQ; Loewy et al., 2005) was developed and tested in a general help-seeking population. We assessed a consecutive patient sample of 3533 young adults who were help-seeking for nonpsychotic disorders at the secondary mental health services in the Hague with the PQ. We performed logistic regression analyses and CHi-squared Automatic Interaction Detector decision tree analysis to shorten the original 92 items. Receiver operating characteristic curves were used to examine the psychometric properties of the PQ-16. In the general help-seeking population, a cutoff score of 6 or more positively answered items on the 16-item version of the PQ produced correct classification of Comprehensive Assessment of At-Risk Mental State (Yung et al., 2005) psychosis risk/clinical psychosis in 44% of the cases, distinguishing Comprehensive Assessment of At-Risk Mental States (CAARMS) diagnosis from no CAARMS diagnosis with high sensitivity (87%) and specificity (87%). These results were comparable to the PQ-92. The PQ-16 is a good self-report screen for use in secondary mental health care services to select subjects for interviewing for psychosis risk. The low number of items makes it quite appropriate for screening large help-seeking populations, thus enhancing the feasibility of detection and treatment of ultra high-risk patients in routine mental health services.