Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.
Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.
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DOI：
10.1186/s13287-015-0150-x
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发表时间：
2015-09-03
影响因子：
7.5
通讯作者：
Camussi G
中科院分区：
文献类型：
--
作者：
Quesenberry PJ;Aliotta J;Deregibus MC;Camussi G
越来越多的证据表明，封装在膜囊泡内的转录调节因子和分泌的 RNA 分子可以改变靶细胞的表型。由细胞主动释放的膜囊泡代表了一种进化上保守的细胞间通讯机制，涉及能够诱导受体细胞表观遗传变化的分子转移。细胞外囊泡，包括外泌体和微囊泡，携带蛋白质、生物活性脂质和核酸，这些蛋白质、生物活性脂质和核酸受到保护，免受酶降解。这些囊泡可以传递能够改变细胞功能和/或重新编程靶细胞的信号。在本综述中，我们重点关注细胞外囊泡诱导的受体细胞表观遗传变化，这些变化可能导致表型和功能修饰。讨论了这些现象在干细胞生物学和组织修复中的相关性。
Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. Extracellular vesicles, which include exosomes and microvesicles, carry proteins, bioactive lipids, and nucleic acids, which are protected from enzyme degradation. These vesicles can transfer signals capable of altering cell function and/or reprogramming targeted cells. In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. The relevance of these phenomena in stem cell biology and tissue repair is discussed.