Short-term effects of exposure to particulate matter and air pollution on hospital admissions for asthma and chronic obstructive pulmonary disease in Gyeonggi-do, South Korea, 2007-2018
Short-term effects of exposure to particulate matter and air pollution on hospital admissions for asthma and chronic obstructive pulmonary disease in Gyeonggi-do, South Korea, 2007-2018
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DOI：
10.1007/s40201-021-00709-7
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发表时间：
2021-07-15
影响因子：
3.4
通讯作者：
Chung, Jae Ho
中科院分区：
文献类型：
--
作者：
Han, Chang Hoon;Pak, Haeyong;Chung, Jae Ho
目标 目前尚缺乏关于接触颗粒物 (PM) 和空气污染对慢性阻塞性肺病 (COPD) 或哮喘患者影响的研究。因此，我们研究了各种空气污染因素对哮喘和慢性阻塞性肺病住院的影响。方法 我们获得了韩国京畿道的污染物 PM10、PM2.5、一氧化碳 (CO)、臭氧 (O-3)、二氧化氮 (NO2) 和二氧化硫 (SO2) 数据。我们还从韩国国民健康保险记录中提取数据，并调查了 2007 年 1 月至 2018 年 2 月期间需要住院的哮喘和慢性阻塞性肺病发作。我们使用具有泊松分布和对数变换的广义加性模型来计算调整后的风险。使用时间分层病例交叉设计，并进行条件逻辑回归来分析这些数据。结果 不同最佳滞后天 PM10、PM2.5、SO2、NO2、CO 和 O-3 浓度每单位的增加与 COPD 和哮喘入院风险增加相关。 SO2 对哮喘入院的影响最强（比值比 [OR]，1.535；95% 置信区间 [CI]，1.450-1.619）。 SO2 对 COPD 入院的影响也最强（OR，1.659；95% CI，1.541-1.786）。亚组分析表明，这些关系在患有哮喘的老年人（≥ 65 岁）和女性中比在患有 COPD 的男性和非老年人中更强。结论 短期暴露于 PM10、PM2.5、CO、O-3、NO2 和 SO2 可能导致哮喘和 COPD 住院。在这些污染物中，SO2 的影响最强。因此，慢性阻塞性肺病和哮喘患者应注意不要在SO2水平较高时进行户外活动。
Objectives Research is lacking on the impacts of exposure to particulate matter (PM) and air pollution on patients with chronic obstructive pulmonary disease (COPD) or asthma. Therefore, we investigate the effects of various air pollution factors on hospitalization for asthma and COPD. Methods We obtained data on pollutants-PM10, PM2.5, carbon monoxide (CO), ozone (O-3), nitrogen dioxide (NO2), and sulfur dioxide (SO2)-in Gyeonggi-do, South Korea. We also extracted data from Korean National Health Insurance records and investigated asthma and COPD attacks that required hospitalization from January 2007 through February 2018. We used generalized additive models with Poisson distribution and log transformation to calculate adjusted risk. A time-stratified case-crossover design was used, and conditional logistic regression was performed to analyze these data. Results Per-unit increases in concentrations of PM10, PM2.5, SO2, NO2, CO, and O-3 on different best lag days were associated with increased risks for hospital admission for COPD and asthma. SO2 had the strongest effect on hospital admission for asthma (odds ratio [OR], 1.535; 95 % confidence interval [CI], 1.450-1.619). SO2 also had the strongest effect on hospital admission for COPD (OR, 1.659; 95 % CI, 1.541-1.786). Subgroup analyses showed that these relationships were stronger in seniors (>= 65 years old) and women with asthma than in men and nonseniors with COPD. Conclusions Short-term exposure to PM10, PM2.5, CO, O-3, NO2, and SO2 may result in hospitalization for asthma and COPD. Of these pollutants, SO2 has the strongest effects. Therefore, patients with COPD and asthma should be cautioned against performing outdoor activities when SO2 levels are high.