A probiotic lozenge administered medical device and its effect on salivary mutans streptococci and lactobacilli
A probiotic lozenge administered medical device and its effect on salivary mutans streptococci and lactobacilli
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DOI：
10.1111/j.1365-263x.2007.00866.x
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Sandalli, Nuket
中科院分区：
文献类型：
--
作者：
Caglar, Esber;Kuscu, Ozgur Onder;Sandalli, Nuket
背景此前的研究表明，乳制品中的乳杆菌衍生益生菌可能会影响口腔生态，但不同给药方式的影响却很少受到关注。本研究的目的是调查益生菌罗伊氏乳杆菌的效果，提供了一种新的医疗设备，对唾液中的变形链球菌和乳酸杆菌的水平与高变形链球菌计数的年轻女性。这是一项随机、双盲、安慰剂对照研究，纳入20名健康年轻女性（年龄20岁）：10名为受试者，10名为对照。研究受试者（A组）吸吮含有益生菌含片的医疗器械，其中L。罗伊氏菌ATCC 55730/L。reuteri ATCC PTA 5289（1.1 × 10（8）CFU），每日一次，持续10天，而对照受试者（组B）接受不含细菌的安慰剂医疗器械。在基线和最后一次摄入后1天，用椅旁试剂盒计数唾液变形链球菌和乳酸杆菌。Salivary S.益生菌试验组变形菌水平明显降低，降低幅度具有统计学意义（P <0. 05）。通过含有益生菌锭剂的医疗装置递送的乳酸杆菌衍生的益生菌的短期每日摄入降低了唾液变形菌的水平。
Background. Previous studies have suggested that lactobacilli-derived probiotics in dairy products may affect oral ecology, but the effects of different delivery methods have received little attention.Aim. The aim of the present study was to investigate the effect of the probiotic Lactobacillus reuteri, delivered by a new medical device, on the levels of salivary mutans streptococci and lactobacilli in young women with high Streptococcus mutans counts.Design. This is a randomized, double-blind, placebo-controlled study involving 20 healthy young women (aged 20 years): 10 as subjects and 10 as controls. The study subjects (Group A) sucked the medical device containing the probiotic lozenge with L. reuteri ATCC 55730/L. reuteri ATCC PTA 5289 (1.1 x 10(8) CFU) once daily for 10 days, while the control subjects (Group B) received placebo medical devices without bacteria. Salivary mutans streptococci and lactobacilli were enumerated with chair-side kits at baseline and 1 day after the final ingestion.Results. Salivary S. mutans levels in the probiotic test group were significantly reduced, with statistical significance of reduction (P < 0.05).Conclusions. A short-term daily ingestion of lactobacilli-derived probiotics delivered via medical device containing probiotic lozenge reduced the levels of salivary mutans.