The existence of two forms of hypertensin.
The existence of two forms of hypertensin.
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DOI：
10.1084/jem.99.3.275
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发表时间：
1954-03
期刊：
影响因子：
--
通讯作者：
SHUMWAY NP
中科院分区：
文献类型：
--
作者：
SKEGGS LT Jr;MARSH WH;KAHN JR;SHUMWAY NP
两种类型的高血压已被证明是通过逆流分布。第一种类型是酶（肾素）作用于其底物的产物，称为高血压Ⅰ。它可以迅速转化为第二种大致相等的升压化合物，高血压II，显然是通过血浆中需要卤化物或硝酸盐激活的酶的作用。一种含有马高血压蛋白I和II的高纯度制剂，当注射到人体内时会引起血压升高。
Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypertensin II, apparently through the action of an enzyme in the plasma which requires halide or nitrate for activation. A highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.