Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors:: A study of preoperative treatment
Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors:: A study of preoperative treatment
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DOI：
10.1158/1078-0432.ccr-04-0380
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发表时间：
2004-10-01
影响因子：
11.5
通讯作者：
Goldhirsch, A
中科院分区：
文献类型：
--
作者：
Colleoni, M;Viale, G;Goldhirsch, A
目的：本研究的目的是确定预测术前化疗反应的因素。 实验设计：在一个使用标准免疫组织化学方法的大型实验室中，我们回顾了 399 名接受术前化疗的大或局部晚期乳腺癌（cT2-T4、N0-2、M0）患者在最终手术时的治疗前活检和组织学标本。根据最初的病理和临床结果评估最终手术时病理完全缓解的发生率和淋巴结阴性状态的发生率。考虑了绝经状态、雌激素受体状态、孕激素受体状态[不存在（0%的细胞呈阳性）与表达]、临床肿瘤大小、组织学分级、Ki-67、Her-2/neu表达以及化疗的类型和途径。结果：较高的病理完全缓解率与雌激素受体和孕激素受体表达的缺失（P < 0.0001）和3级（P = 0.001）。手术时淋巴结阴性状态的重要预测因素是缺乏雌激素受体和孕激素受体表达（P < 0.0001）、临床肿瘤大小
Purpose: The purpose of this research was to identify factors predicting response to preoperative chemotherapy.Experimental Design: In a large volume laboratory using standard immunohistochemical methods, we reviewed the pretreatment biopsies and histologic specimens at final surgery of 399 patients with large or locally advanced breast cancer (cT2-T4, N0-2, M0) who were treated with preoperative chemotherapy. The incidence of pathological complete remission and the incidence of node-negative status at final surgery were assessed with respect to initial pathological and clinical findings. Menopausal status, estrogen receptor status, progesterone receptor status [absent (0% of the cells positive) versus expressed], clinical tumor size, histologic grade, Ki-67, Her-2/neu expression, and type and route of chemotherapy were considered.Results: High rates of pathological complete remission were associated with absence of estrogen receptor and progesterone receptor expression (P < 0.0001), and grade 3 (P = 0.001). Significant predictors of node-negative status at surgery were absence of estrogen receptor and progesterone receptor expression (P < 0.0001), clinical tumor size