Molecular mechanisms of antibiotic resistance
Molecular mechanisms of antibiotic resistance
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DOI：
10.1039/c0cc05111j
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Wright, Gerard D.
中科院分区：
文献类型：
--
作者：
Wright, Gerard D.
在过去十年中，对抗生素的耐药性已经成为一场全球性的危机。对许多甚至所有临床批准的抗生素具有耐药性的微生物越来越普遍，并且很容易在各大洲传播。与此同时，进入市场的抗生素新药越来越少。我们正在达到一个点，我们不再能够自信地治疗越来越多的细菌感染。耐药的分子机制为新药开发和临床应用提供了必要的知识。这些机制包括酶催化的抗生素修饰、绕过抗生素靶标和药物从细胞中主动流出。了解耐药性的化学原理和基础是我们应对这一临床挑战的重要组成部分。
Over the past decade, resistance to antibiotics has emerged as a crisis of global proportion. Microbes resistant to many and even all clinically approved antibiotics are increasingly common and easily spread across continents. At the same time there are fewer new antibiotic drugs coming to market. We are reaching a point where we are no longer able to confidently treat a growing number of bacterial infections. The molecular mechanisms of drug resistance provide the essential knowledge on new drug development and clinical use. These mechanisms include enzyme catalyzed antibiotic modifications, bypass of antibiotic targets and active efflux of drugs from the cell. Understanding the chemical rationale and underpinnings of resistance is an essential component of our response to this clinical challenge.