Breastfeeding status at age 3 months is associated with adiposity and cardiometabolic markers at age 4 years in Mexican children.
Breastfeeding status at age 3 months is associated with adiposity and cardiometabolic markers at age 4 years in Mexican children.
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DOI：
10.3945/jn.114.198366
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
I. Ramírez-Silva;J. Rivera;B. Trejo-Valdivia;R. Martorell;A. Stein;I. Romieu;A. Barraza‐Villarreal;U. Ramakrishnan
中科院分区：
文献类型：
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作者：
I. Ramírez-Silva;J. Rivera;B. Trejo-Valdivia;R. Martorell;A. Stein;I. Romieu;A. Barraza‐Villarreal;U. Ramakrishnan
背景母乳喂养对心脏代谢危险因素的影响还没有得到很好的表征。目的：评估3个月时BF状态和持续时间与4年时肥胖和心脏代谢标志物的相关性。方法：我们研究了727名儿童，前瞻性收集了4年时的BF信息和人体测量数据，其中524名提供了非空腹血液样本。将3个月时的BF状态分类为完全或主要（EBF-PreBF）、部分（PaBF）或非母乳喂养（NBF）。任何BF的总持续时间被分类为6至12个月，以及>12个月。我们建立了4年时BF与体重指数（BMI;单位：kg/m2）、血清总胆固醇和低密度脂蛋白（LDL）胆固醇、甘油三酯（TG）和胰岛素的关系模型。结果3个月时NBF或PaBF儿童的BMI [分别为0.46（95%CI：0.16，0.76）和0.31（95%CI：0.07，0.54）]高于EBF-PreBF组（P 12个月时。结论3个月时的EBF和PreBF与4岁时儿童的低脂肪和血清总胆固醇有关。此外，BF >12个月与较低的肥胖有关。这些数据证实了专用BF和延长BF对以后心脏代谢健康的重要性。
BACKGROUND The effect of breastfeeding (BF) on cardiometabolic risk factors is not well characterized. OBJECTIVE The objective was to assess the association of BF status at 3 mo and duration with adiposity and cardiometabolic markers at 4 y. METHODS We studied 727 children with prospectively collected BF information and anthropometric measurements at 4 y, of whom 524 provided a nonfasting blood sample. BF status at 3 mo was classified as exclusive or predominant (EBF-PreBF), partial (PaBF), or nonbreastfeeding (NBF). Total duration of any BF was classified as 6 to 12 mo, and >12 mo. We modeled associations of BF with body mass index (BMI; in kg/m(2)), serum total cholesterol and low-density lipoprotein (LDL) cholesterol, triglycerides (TGs), and insulin at 4 y. RESULTS Children who were NBF or PaBF at 3 mo had higher BMI [0.46 (95% CI: 0.16, 0.76) and 0.31 (95% CI: 0.07, 0.54), respectively] than the EBF-PreBF group (P 12 mo. CONCLUSION EBF and PreBF at 3 mo were associated with lower adiposity and serum total cholesterol in children at 4 y. In addition, BF >12 mo was associated with lower adiposity. These data confirm the importance of exclusive BF and prolonged BF for later cardiometabolic health.