Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease.
Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease.
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DOI：
10.3390/nu5051544
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发表时间：
2013-05-10
期刊：
影响因子：
5.9
通讯作者：
Gastaldelli A
中科院分区：
文献类型：
--
作者：
Gaggini M;Morelli M;Buzzigoli E;DeFronzo RA;Bugianesi E;Gastaldelli A
非酒精性脂肪肝的特点是肝脏脂肪堆积，而不是由于酒精滥用。几项研究表明，NAFLD与胰岛素抵抗相关，导致胰岛素在脂肪组织中的抗脂解作用抵抗，游离脂肪酸（FFA）增加。游离脂肪酸的增加诱导线粒体功能障碍和脂毒性的发展。此外，在患有NAFLD的受试者中，异位脂肪也积累为心脏和胰腺脂肪。本文就NAFLD与代谢综合征、血脂异常的相关机制及其与心血管疾病发生、发展的关系作一综述。
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.
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影响因子：
7.6
作者：
Gastaldelli, A.;Harrison, S.;Cusi, K.
通讯作者：
Cusi, K.
影响因子：
29.4
作者：
Fabbrini E;Tamboli RA;Magkos F;Marks-Shulman PA;Eckhauser AW;Richards WO;Klein S;Abumrad NN
通讯作者：
Abumrad NN
影响因子：
39.3
作者：
Chapman MJ;Ginsberg HN;Amarenco P;Andreotti F;Borén J;Catapano AL;Descamps OS;Fisher E;Kovanen PT;Kuivenhoven JA;Lesnik P;Masana L;Nordestgaard BG;Ray KK;Reiner Z;Taskinen MR;Tokgözoglu L;Tybjærg-Hansen A;Watts GF;European Atherosclerosis Society Consensus Panel
通讯作者：
European Atherosclerosis Society Consensus Panel
影响因子：
3.2
作者：
Day, CP
通讯作者：
Day, CP
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH