SOME OBSERVATIONS ON THE PHARMACOLOGY OF DEEP-HEAT, A TOPICAL RUBIFACIENT
SOME OBSERVATIONS ON THE PHARMACOLOGY OF DEEP-HEAT, A TOPICAL RUBIFACIENT
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DOI：
10.1136/ard.43.3.411
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发表时间：
1984-01-01
影响因子：
27.4
通讯作者：
SEED, MP
中科院分区：
文献类型：
--
作者：
COLLINS, AJ;NOTARIANNI, LJ;SEED, MP
研究了一种局部应用的由气雾剂（Deep-Heat）递送的发红剂。在不按摩的情况下，将喷雾剂应用于志愿者的前臂后，通过热成像法测量产生的红斑，并将其与在局部和全身静脉血中发现的混合物的2种水杨酸盐组分的浓度相关联。最大红斑发生在约30分钟，而血液水杨酸盐水平最大的应用后20和30分钟之间。水杨酸甲酯在水杨酸乙酯之前被吸收。在痉挛反应的时间段内，局部静脉血中的氧水平升高。最后，从喷洒部位排出的静脉血中收集的血小板，当通过在聚集计中加入花生四烯酸诱导成团时，与对照细胞相比，显示出对成团的抵抗力增加。本文还讨论了这些现象的发生机理和深层热成分的作用方式。
A topically applied rubifacient delivered by aerosol (Deep-Heat) was studied. After spray application to the forearms of volunteers, without massage, the erythema produced was measured by thermography and correlated with the concentration of 2 salicylate components of the mixture found in local and systemic venous blood. Maximum erythema occurred at about 30 minutes, while blood salicylate levels were maximal between 20 and 30 minutes after application. Methyl salicylate was absorbed before ethyl salicylate. Over the time period of the erythematous response oxygen levels in local venous blood were raised. Finally, platelets collected from venous blood draining from the sprayed site, when induced to clump by the addition of arachidonic acid in an aggregometer, showed increased resistance to clumping when compared with control cells. The mechanism of these observed phenomena and the mode of action of the constituents of Deep-Heat are discussed.