Value of flow diagrams in reports of randomized controlled trials
Value of flow diagrams in reports of randomized controlled trials
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DOI：
10.1001/jama.285.15.1996
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发表时间：
2001-04-18
影响因子：
120.7
通讯作者：
Bartlett, C
中科院分区：
文献类型：
--
作者：
Egger, M;J端ni, P;Bartlett, C
试验报告综合标准 (CONSORT) 声明中推荐了参与者通过临床试验的流程的背景图，但尚不清楚此类流程图是否可以提高试验报告的质量。 目的 检查 5 种普通医学和内科期刊上发表的随机对照试验 (RCT) 报告中流程图提供的信息和总体报告的完整性。 对 270 份 RCT 报告的设计和设置分析 1998 年发表于《内科年鉴》(AIM；n = 19)、《BMJ》(n = 42)、《JAMA》(n = 45)、《柳叶刀》(n = 81) 和《新英格兰医学杂志》(NEJM；n = 83)。 主要结果指标 包含流程图、流程图中提供的信息以及发表在 5 个一般性和内科杂志。结果 总共 139 份随机对照试验报告 (51.5%) 包含流程图，但不同期刊之间差异很大（AIM，21.0%；BMJ，38.1%；JAMA，80.0%；《柳叶刀》，93.8%；NEJM，8.4%）。图表通常提供了有用的信息，但只有 73 个 (52.5%) 包含了接受分配干预措施的参与者人数，只有 32 个 (23.0%) 包含了分析中的参与者人数。在逻辑回归分析中，研究参与者流程报告的整体完整性与流程图的发布相关。结论 流程图与随机对照试验报告质量的提高相关。然而，电流流程图的结构并不理想。我们提出了一个修订后的流程图，其中包括流程图或文本中参与者的所有重要计数。平行小组试验的阶段。
Context Diagrams of the flow of participants through a clinical trial are recommended in the Consolidated Standards for Reporting of Trials (CONSORT) statement, but it is unclear whether such flow diagrams improve the quality of trial reports.Objective To examine the information contributed by flow diagrams and the completeness of reporting overall in reports of randomized controlled trials (RCTs) published in 5 general and internal medicine journals.Design and Setting Analysis of 270 reports of RCTs published in 1998 in the Annals of Internal Medicine (AIM; n = 19), BMJ (n = 42), JAMA (n = 45), The Lancet (n = 81), and The New England Journal of Medicine (NEJM; n = 83).Main Outcome Measures Proportion of reports that included a flow diagram, information provided in flow diagrams, and completeness of reporting about flow of published in 5 general and internal medicine journals. participants overall in flow diagrams or text.Results A total of 139 reports (51.5%) of RCTs included a flow diagram, but this varied widely among journals (AIM, 21.0%; BMJ, 38.1%; JAMA, 80.0%; The Lancet, 93.8%; and NEJM, 8.4%). Diagrams generally provided useful information, but only 73 (52.5%) included the number of participants who received allocated interventions and only 32 (23.0%) included the number of participants included in the analysis. In logistic regression analysis, overall completeness of reporting about flow of study participants was associated with publication of a flow diagram.Conclusions Flow diagrams are associated with improved quality of reporting of randomized controlled trials. However, the structure of current flow diagrams is less than ideal. We propose a revised flow diagram that includes all important counts through participants overall in flow diagrams or text. the stages of parallel group trials.