Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?
Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?
复制标题
DOI：
10.1007/s11906-012-0310-7
复制
发表时间：
2012-12-01
影响因子：
5.6
通讯作者：
Martins, Paula A. da Costa
中科院分区：
文献类型：
--
作者：
van Empel, Vanessa P. M.;De Windt, Leon J.;Martins, Paula A. da Costa
microRNA是一类由后生动物基因组编码的调节蛋白质表达的小的非编码RNA。一系列研究指出microRNA在心血管疾病的发生和发展中的重要作用。迄今为止，microRNA被认为是维持心脏正常功能和止血的重要细胞内介质，并被认为是心血管疾病潜在的治疗靶点。最近发现microRNA在许多体液（包括血液）中以稳定的形式循环，这表明循环microRNA可以作为新一代心血管疾病的生物标志物。在这篇综述中，我们总结了研究的结果，重点是循环microRNA存在于人类血细胞或血浆/血清，在那里他们可能作为诊断或预后标记物的各种心血管疾病，包括急性心肌梗死，心力衰竭，冠状动脉疾病，中风，糖尿病和高血压。本文还讨论了microRNA作为心血管疾病新一代生物标志物的意义和局限性。
MicroRNAs are a class of small, noncoding RNAs encoded by the metazoan genome that regulate protein expression. A collection of studies point to vital roles for microRNAs in the onset and development of cardiovascular diseases. So far, microRNAs have been considered as important intracellular mediators in maintaining proper cardiac function and hemostasis, and have been proposed as potential therapeutic targets in cardiovascular disease. The recent discovery that microRNAs circulate in a stable form in many body fluids, including blood, suggests that circulating microRNAs can serve as a new generation of biomarkers for cardiovascular diseases. In this review, we summarize the findings of studies focusing on circulating microRNAs present in human blood cells or plasma/serum, where they potentially could serve as diagnostic or prognostic markers for a variety of cardiovascular pathologies, including acute myocardial infarction, heart failure, coronary artery disease, stroke, diabetes and hypertension. The significance and limitations of microRNAs as the new biomarker generation for cardiovascular disease are also discussed.