EFFECTS OF TRANSITORY COGNITIVE IMPAIRMENT ON PSYCHOSOCIAL FUNCTIONING OF CHILDREN WITH EPILEPSY: A THERAPEUTIC TRIAL
EFFECTS OF TRANSITORY COGNITIVE IMPAIRMENT ON PSYCHOSOCIAL FUNCTIONING OF CHILDREN WITH EPILEPSY: A THERAPEUTIC TRIAL
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DOI：
10.1111/j.1469-8749.1993.tb11694.x
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发表时间：
1993-07
影响因子：
3.8
通讯作者：
D. Marston;F. Besag;Colin D. Binnie;M. Fowler
中科院分区：
文献类型：
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作者：
D. Marston;F. Besag;Colin D. Binnie;M. Fowler
作者报告了一项试验，使用抗癫痫药物治疗10名患有癫痫相关心理社会和教育问题的儿童因亚临床癫痫样EEG放电导致的可能认知缺陷。在儿童现有的药物治疗方案中增加了抑制EEG放电的药物。在所有情况下，癫痫样活动。通过24小时动态监测进行评估，与安慰剂相比，活性药物治疗组的死亡率降低。总体而言，积极治疗的心理社会功能有所改善：8名儿童改善，1名儿童无变化，1名儿童恶化。在完成试验的患者中未检测到可归因于药物不良反应的心理社会恶化。尽管存在可能的混杂因素，但研究结果与亚临床EEG放电可能损害心理社会功能的观点一致，这可能通过抗癫痫药物改善。
The authors report a trial of the use of anti‐epileptic medication to treat possible cognitive deficits due to subclinical epileptiform EEG discharges in 10 children with psychosocial and educational problems associated with epilepsy. Medication intended to suppress the EEG discharges was added to the children's existing drug regime. In all instances, epileptiform activity. assessed by 24‐hour periods of ambulatory monitoring, was reduced on active medication compared with placebo. In general, there was improvement of psychosocial function on active treatment: eight children improved, there was no change in one and one deteriorated. No psychosocial deterioration attributable to adverse effects of the medication was detected in those completing the trial. Despite possible confounding factors, the findings are in accordance with the view that subclinical EEG discharges can impair psychosocial function, which may be ameliorated by anti‐epileptic medication.