BRUCELLA-SUIS S2, BRUCELLA-MELITENSIS REV-1 AND BRUCELLA-ABORTUS S19 LIVING VACCINES - RESIDUAL VIRULENCE AND IMMUNITY INDUCED AGAINST 3 BRUCELLA SPECIES CHALLENGE STRAINS IN MICE
BRUCELLA-SUIS S2, BRUCELLA-MELITENSIS REV-1 AND BRUCELLA-ABORTUS S19 LIVING VACCINES - RESIDUAL VIRULENCE AND IMMUNITY INDUCED AGAINST 3 BRUCELLA SPECIES CHALLENGE STRAINS IN MICE
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DOI：
10.1016/0264-410x(90)90247-j
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发表时间：
1990-10-01
期刊：
影响因子：
5.5
通讯作者：
PLOMMET, M
中科院分区：
文献类型：
--
作者：
BOSSERAY, N;PLOMMET, M
在小鼠体内将减毒猪布鲁氏菌 S2 活疫苗与流产布鲁氏菌 S19 和羊布鲁氏菌 Rev.1 活疫苗进行比较。通过在脾脏和淋巴结中增殖和持续的能力来估计残余毒力。通过用参考流产布鲁氏菌 544 菌株或用有毒力的羊种布鲁氏菌 H38 和猪布鲁氏菌 1330 菌株攻击的对照小鼠和接种疫苗的小鼠的脾脏计数来估计免疫原性。 S2疫苗残留毒力较低；以 50% 恢复时间表示，持续时间为 4.3 周，而 S19 和 Rev.1 疫苗为 7.1 和 9.0 周。接种后 45 天，三种疫苗诱导的免疫力相似。 150 天时，S19 和 Rev.1 对三种攻击菌株的免疫力仍然相似。相比之下，S2 诱导的针对羊种芽孢杆菌菌株的免疫力有所下降。因此，羊的疫苗接种可能需要召回疫苗以赋予持久的免疫力。
Live attenuated Brucella suis S2 vaccine was compared to living vaccines B. abortus S19 and B. melitensis Rev.1 in mice. Residual virulence was estimated by ability to multiply and persist in spleen and lymph nodes. Immunogenicity was estimated by spleen counts of control and vaccinated mice challenged either with the reference B. abortus 544 strain or with virulent B. melitensis H38 and B. suis 1330 strains. S2 vaccine had lower residual virulence; expressed as 50% recovery time, persistence was 4.3 weeks, compared to 7.1 and 9.0 weeks for S19 and Rev.1 vaccines. Immunity induced by the three vaccines was similar 45 days after vaccination. At 150 days, immunity by S19 and Rev.1 was still similar against the three challenge strains. In contrast, immunity induced by S2 had declined against the B. melitensis strain. Thus, a recall vaccination may be required for vaccination of sheep to confer a long-lasting immunity.