Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization.
Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization.
复制标题
间充质基质细胞通过巨噬细胞极化影响疾病结果。
DOI：
10.1155/2015/989473
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发表时间：
2015
影响因子：
4.3
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Zheng G;Ge M;Qiu G;Shu Q;Xu J
间充质基质细胞（MSCs）是多能且可自我更新的细胞，存在于几乎所有的出生后组织中。近年来，许多研究报道了MSCs对固有免疫系统和适应性免疫系统的影响。MSCs通过直接的细胞间接触或产生可溶性因子（包括吲哚胺2,3 - 双加氧酶、前列腺素E2、肿瘤坏死因子 -α刺激基因/蛋白6、一氧化氮和白细胞介素 - 10）来调节T淋巴细胞、专职抗原呈递细胞（树突状细胞、巨噬细胞和B淋巴细胞）以及自然杀伤细胞的增殖、活化和效应功能。MSCs还能够将巨噬细胞从促炎的M1表型重编程为具有调节免疫反应能力的抗炎M2表型。由于其分化和免疫调节能力，MSCs已在许多临床前和临床研究中被用作治疗自身免疫性、退行性和炎性疾病的可能的新型治疗剂。在这篇综述中，我们讨论了MSCs在巨噬细胞极化中的核心作用以及在动物模型中诸如伤口愈合、脑/脊髓损伤以及心、肺和肾疾病等疾病的转归。
Mesenchymal stromal cells (MSCs) are multipotent and self-renewable cells that reside in almost all postnatal tissues. In recent years, many studies have reported the effect of MSCs on the innate and adaptive immune systems. MSCs regulate the proliferation, activation, and effector function of T lymphocytes, professional antigen presenting cells (dendritic cells, macrophages, and B lymphocytes), and NK cells via direct cell-to-cell contact or production of soluble factors including indoleamine 2,3-dioxygenase, prostaglandin E2, tumor necrosis factor-α stimulated gene/protein 6, nitric oxide, and IL-10. MSCs are also able to reprogram macrophages from a proinflammatory M1 phenotype toward an anti-inflammatory M2 phenotype capable of regulating immune response. Because of their capacity for differentiation and immunomodulation, MSCs have been used in many preclinical and clinical studies as possible new therapeutic agents for the treatment of autoimmune, degenerative, and inflammatory diseases. In this review, we discuss the central role of MSCs in macrophage polarization and outcomes of diseases such as wound healing, brain/spinal cord injuries, and diseases of heart, lung, and kidney in animal models.