Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process?
Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process?
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DOI：
10.1007/s10577-011-9257-9
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发表时间：
2012-01-01
影响因子：
2.6
通讯作者：
McBride, D.
中科院分区：
文献类型：
--
作者：
Clinton, M.;Zhao, D.;McBride, D.
对于大多数动物来说，雄性和雌性在外观、行为和生理方面都有明显的不同，直到最近，这些差异还被认为是激素作用的结果。然而，现在有大量证据表明，一些性二态性结构/行为的发展是男性和女性细胞固有特性的函数（与激素无关）。激素和细胞特性对表型发展的相对贡献尚不清楚，并且可能因物种而异。对雌雄同体鸟类和嵌合胚胎的研究极大地帮助了区分激素和固有细胞因素对表型的影响。现在很清楚，在鸟类中，雄性/雌性差异主要不是激素作用的结果，并且雄性和雌性体细胞拥有细胞自主性别认同（CASI）。在这里，我们回顾了鸟类 CASI 的证据，并讨论了其对性别决定过程的影响。
For the majority of animals, males and females are obviously different in terms of appearance, behaviour and physiology, and until recently, these differences were considered to be the result of hormone actions. However, there is now considerable evidence that the development of some sexually dimorphic structures/behaviours is a function of properties inherent to male and female cells (hormone independent). The relative contribution of hormones and cellular identity to the development of the phenotype is not clear and is likely to vary from species to species. The study of gynandromorph birds and chimeric embryos has greatly assisted efforts to distinguish between the effects of hormones and inherent cellular factors on phenotype. It is now clear that in birds, male/female differences are not primarily the result of hormone action and that male and female somatic cells possess a cell autonomous sex identity (CASI). Here, we review evidence for CASI in birds and discuss the implications for the process of sex determination.