Cognitive ERPs in depressive and anxiety disorders during tonal and phonetic oddball tasks
Cognitive ERPs in depressive and anxiety disorders during tonal and phonetic oddball tasks
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DOI：
10.1177/155005940203300308
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发表时间：
2002-07-01
期刊：
影响因子：
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通讯作者：
Quitkin, FM
中科院分区：
文献类型：
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作者：
Bruder, GE;Kayser, J;Quitkin, FM
本报告比较了抑郁症患者（n=58），焦虑症患者（n=22），这些疾病的合并症（n=18）和健康对照组（n=49）的事件相关脑电位（ERP）。在听觉oddball任务期间，使用辅音-元音音节（语音）或复杂音调（音调）从30个电极部位记录ERPs。重叠的ERP组件进行了识别和测量，使用基于协方差的主成分分析。与伴或不伴焦虑障碍的抑郁症患者和健康对照组相比，单独患有焦虑障碍的患者的早期P3亚成分（P315）更大，而焦虑和抑郁障碍共病患者的晚期P3亚成分（P400）更大。此外，N2-P3复合体表现出任务依赖的半球不对称性，包括更大的N2-P3振幅比右颞顶左侧网站在语音oddball任务。这种大脑半球的不对称性在单独患有抑郁症的患者中最大，在单独患有焦虑症的患者中最小。抑郁症和焦虑症的半球不对称性和早期P3振幅的改变的相反性质强调了在抑郁症的认知ERP研究中考虑与焦虑的共病的重要性。
This report compares event-related brain potentials (ERPs) of patients having a depressive disorder alone (n=58), an anxiety disorder alone (n=22), comorbidity of these disorders (n=18), and healthy controls (n=49). ERPs; were recorded from 30 electrode sites during auditory oddball tasks using consonant-vowel syllables (phonetic) or complex tones (tonal). Overlapping ERP components were identified and measured using covariance-based principal components analysis. An early P3 subcomponent (P315) was larger in patients having an anxiety disorder alone when compared to depressed patients with or without an anxiety disorder and healthy controls, whereas a late P3 subcomponent (P400) was larger in patients having comorbidity of anxiety and depressive disorders than in the other groups. Also, the N2-P3 complex showed task-dependent hemispheric asymmetries, including larger N2-P3 amplitude over left than right temporoparietal sites during the phonetic oddball task. This hemispheric asymmetry was greatest in patients having a depressive disorder alone and smallest in patients having an anxiety disorder alone. The opposite nature of the alterations of hemispheric asymmetry and early P3 amplitude in depressive and anxiety disorders underscores the importance of taking comorbidity with anxiety into account in studies of cognitive ERPs in depressive disorders.