Post-initiation treatment of rats with indole-3-carbinol or beta-naphthoflavone does not suppress 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis.
Post-initiation treatment of rats with indole-3-carbinol or beta-naphthoflavone does not suppress 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis.
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用吲哚-3-甲醇或β-萘黄酮对大鼠进行启动后治疗不会抑制7, 12-二甲基苯并[a]蒽诱导的乳腺癌发生。
DOI：
10.1016/s0304-3835(00)00594-2
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发表时间：
2000
期刊：
影响因子：
9.7
通讯作者：
Bliss,RL
中科院分区：
文献类型：
--
作者：
Malejka-Giganti,D;Niehans,GA;Reichert,MA;Bliss,RL
吲哚-3-甲醇（Indole-3-carbinol，I3 C）和β-萘甲酮（β-naphthalonone，β-NF）是7，12-二甲基苯并[a]蒽（DMBA）诱发乳腺癌的阻断剂，可作为潜在的启动后抑制剂。用I3 C（250 mg/kg体重（b.w.））处理雌性Sprague-Dawley大鼠，β-NF（20 mg/kg b.w.）或溶剂乙醇：玉米油（2：3）（2.5 ml/kg b.w.），每周三次通过管饲法，在开始后3周以一次口服剂量的DMBA（7周龄时20 mg/大鼠）开始，并持续长达12周。I3 C或β-NF或溶剂给药组在乳腺肿瘤发生的总体结局方面无显著差异，包括每只荷瘤大鼠的累积乳腺肿瘤发生率和多重性、潜伏期以及恶性、良性和/或恶性+良性肿瘤的乳腺肿瘤数量和重量。与β-NF-（1.52± 1.58 g）或溶剂-（1.55±1.53 g）给药组相比，I3 C给药组大鼠发生乳腺腺癌的倾向更少，每只大鼠每个肿瘤的平均重量更大（2.32±1.50 g），这表明I3 C对肿瘤发生和生长的影响尚待证实。I3 C或β-NF处理12周可显著增加肝微粒体中乙氧基、甲氧基、苄氧基和戊氧基（仅I3 C）试卤灵O-脱烷基酶的P450依赖性活性，表明诱导了几种P450。P450补体的改变可能在分子水平上影响内源性雌激素代谢以及乳腺和肿瘤特征，例如雌激素受体状态和/或增殖活性，这需要进一步研究。
Indole-3-carbinol (I3C) and β-naphthoflavone (β-NF), blocking agents of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mammary gland carcinogenesis, were examined as potential post-initiation suppressing agents. Treatment of female Sprague–Dawley rats with I3C (250 mg/kg body weight (b.w.)), β-NF (20 mg/kg b.w.) or the vehicle ethanol:corn oil (2:3) (2.5 ml/kg b.w.), three times weekly by gavage, started 3 weeks after the initiation with one oral dose of DMBA (20 mg/rat at 7 weeks of age) and continued for up to 12 weeks. I3C- or β-NF- or vehicle-treated groups did not differ significantly in the overall outcome of mammary tumorigenesis including cumulative mammary tumor incidences and multiplicities, latent periods and number and weight of mammary tumors per tumor-bearing rat for malignant, benign and/or malignant + benign tumors. A tendency of the I3C-treated rats to develop fewer mammary adenocarcinomas with a greater average weight per tumor per rat (2.32±1.50 g) than in the β-NF- (1.52±1.58 g) or vehicle- (1.55±1.53 g) treated groups suggests an effect, yet to be confirmed, of I3C on tumor development and growth. A 12-week treatment with I3C or β-NF significantly increased the P450-dependent activities of ethoxy-, methoxy-, benzyloxy- and pentoxy-(with I3C only) resorufin O-dealkylase in hepatic microsomes indicating induction of several P450s. The alterations in the P450 complement may affect endogenous estrogen metabolism and mammary gland and tumor characteristics at the molecular level, e.g. estrogen receptor status and/or proliferative activity, which require further studies.
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影响因子：
13.5
作者：
S. Safe
通讯作者：
S. Safe
影响因子：
3.5
作者：
Di F. Tenchio
通讯作者：
Di F. Tenchio
哺乳大鼠乳腺和肝微粒体中的混合功能氧化酶。
影响因子：
5.8
作者：
Ritter,CL;Malejka-Giganti,D
通讯作者：
Malejka-Giganti,D
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶诱导的大鼠乳腺癌的化学预防。
影响因子：
9.7
作者：
H. Mori;S. Sugie;W. Rahman;N. Suzui
通讯作者：
N. Suzui
DOI：
10.1093/jnci/86.2.126
发表时间：
1994-01-19
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
TIWARI, RK;GUO, L;OSBORNE, MP
通讯作者：
OSBORNE, MP