A prospective study on the efficacy of two-dose influenza vaccinations in cancer patients receiving chemotherapy
A prospective study on the efficacy of two-dose influenza vaccinations in cancer patients receiving chemotherapy
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DOI：
10.1093/jjco/hyw020
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发表时间：
2016-05-01
影响因子：
2.4
通讯作者：
Minami, Hironobu
中科院分区：
文献类型：
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作者：
Sanada, Yukinari;Yakushijin, Kimikazu;Minami, Hironobu
目的：接受化疗的癌症患者存在感染流感的风险。两剂疫苗接种是一种提高疫苗接种效力的拟议策略;然而，这一点尚未在该人群中得到证实。本研究的目的是阐明这种策略的有效性和安全性。方法：我们进行了一项多中心前瞻性研究，在接受化疗的癌症患者的两剂疫苗接种方案。在第一次接种后对所有三种病毒株均无应答的患者中进行第二次接种。在第一次疫苗接种前2周、每次疫苗接种后3-5周以及流感季节结束时，测量血清血凝抑制滴度，以确定患者的免疫反应。结果：我们招募了109名患者，其中70名实体瘤患者，36名血液学恶性肿瘤患者，3名同时患有两种癌症类型。在所有患者中，对三种病毒株具有保护性滴度的患者比例从3%显著增加到27%（P
Objective: Cancer patients receiving chemotherapy are at risk of acquiring influenza infections. Two-dose vaccination is a proposed strategy for increasing vaccination efficacy; however, this has yet to be confirmed in this population. The purpose of this study was to clarify the efficacy and safety of this strategy.Methods: We conducted a multicentre prospective study on a two-dose vaccination regimen in cancer patients receiving chemotherapy. Second vaccinations were performed in patients who did not respond to all three viral strains after the first vaccination. Serum haemagglutination inhibition titres were measured to determine the patients' immunological response, 2 weeks prior to the first vaccination, 3-5 weeks after each vaccination, and at the end of the influenza season.Results: We enrolled 109 patients, including 70 with solid tumours, 36 with haematological malignancies, and 3 with both cancer types. Among the total patients, the proportion of patients with protective titres against the three viral strains increased significantly from 3 to 27% (P