Imaging local genetic influences on cortical folding
Imaging local genetic influences on cortical folding
复制标题
DOI：
10.1073/pnas.1912064117
复制
发表时间：
2020-03-31
影响因子：
11.1
通讯作者：
Glahn, David C.
中科院分区：
文献类型：
--
作者：
Alexander-Bloch, Aaron F.;Raznahan, Armin;Glahn, David C.
人类大脑皮层折叠机制的最新进展无法解释空间模式的遗传影响是否有助于这种折叠。高分辨率在体内脑MRI可用于估计遗传相关性（由于共享的遗传因素的协变性）在区域间皮质厚度，和生物力学研究预测皮质厚度的影响折叠模式。然而，进展受到阻碍，因为与折叠模式相关的共享遗传影响可能在更局部的规模上起作用（
Recent progress in deciphering mechanisms of human brain cortical folding leave unexplained whether spatially patterned genetic influences contribute to this folding. High-resolution in vivo brain MRI can be used to estimate genetic correlations (covariability due to shared genetic factors) in interregional cortical thickness, and biomechanical studies predict an influence of cortical thickness on folding patterns. However, progress has been hampered because shared genetic influences related to folding patterns likely operate at a scale that is much more local (