Brain metastases from cervical carcinoma
Brain metastases from cervical carcinoma
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DOI：
10.1177/030089169608200420
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发表时间：
1996-07-01
期刊：
影响因子：
1.9
通讯作者：
Mangioni, C
中科院分区：
文献类型：
--
作者：
Cormio, G;Pellegrino, A;Mangioni, C
子宫颈癌侵犯中枢神经系统并不常见。在1982年至1994年在我院登记的1，184例浸润性宫颈癌患者中，14例（1.18%）发生脑转移。CNS转移诊断时的中位年龄为52岁。诊断宫颈癌和记录脑部受累之间的中位间隔为18个月。临床表现为运动无力、头痛、癫痫发作、头晕和视力障碍。所有病灶（8个多发病灶，6个单发病灶）均在计算机断层扫描上进行了对比增强，位于大脑（n=10）、小脑（n=2）或两者兼而有之（n=2）。CNS是7例复发性疾病患者中唯一可检测到的疾病部位。11例患者仅接受类固醇治疗，3例患者接受放疗。所有14例患者均死亡，整个系列诊断为脑转移的中位生存期为4个月（范围，1-21）。宫颈癌的中枢神经系统转移是罕见的，这类患者的预后似乎很差。
Central nervous system (CNS) involvement by cervical carcinoma is uncommon. Out of 1,184 patients registered for invasive cervical carcinoma at our Institution between 1982 and 1994, 14 (1.18%) developed brain metastases. Median age at the time of CNS metastasis diagnosis was 52 years. Median interval between diagnosis of cervical cancer and documentation of brain involvement was 18 months. Clinical manifestation included motor weakness, headache, seizures, dizziness and visual disturbances. All lesions (8 multiple, 6 single) were contrast enhanced on computerized tomography scans and were located in the cerebrum (n=10), in the cerebellum (n=2), or in both (n=2). The CNS was the only site of detectable disease in 7 patients with recurrent disease. Eleven patients received only steroids, and 3 patients received radiotherapy. All 14 patients died, and median survival from diagnosis of brain metastases for the entire series was 4 months (range, 1-21). CNS metastases from cervical cancer are rare, and the prognosis for such patients appears poor.