Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
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DOI：
10.1056/nejmoa022823
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发表时间：
2003-05-01
影响因子：
158.5
通讯作者：
Schuchat, A
中科院分区：
文献类型：
--
作者：
Whitney, CG;Farley, MM;Schuchat, A
背景：2000年初，一种针对七种肺炎球菌血清型的蛋白质-多糖结合疫苗在美国获准用于幼儿。方法：我们检查了疾病控制和预防中心活性细菌核心监测的基于人群的数据，以评估侵袭性疾病负担的变化，侵袭性疾病的定义是从通常无菌的部位分离出肺炎链球菌。对分离株进行血清分型和药敏试验。我们利用1998年至2001年七个地理区域（人口1600万）持续参与的数据来评估趋势。结果：侵袭性疾病发生率由1998年和1999年的平均24.3例/ 10万人下降到2001年的17.3例/ 10万人。降幅最大的是两岁以下的儿童。在这一组中，2001年的发病率比基线发病率低69%（59.0例/ 10万vs 188.0例/ 10万）
BACKGROUND:In early 2000, a protein-polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children.METHODS:We examined population-based data from the Active Bacterial Core Surveillance of the Centers for Disease Control and Prevention to evaluate changes in the burden of invasive disease, defined by isolation of Streptococcus pneumoniae from a normally sterile site. Serotyping and susceptibility testing of isolates were performed. We assessed trends using data from seven geographic areas with continuous participation from 1998 through 2001 (population, 16 million).RESULTS:The rate of invasive disease dropped from an average of 24.3 cases per 100,000 persons in 1998 and 1999 to 17.3 per 100,000 in 2001. The largest decline was in children under two years of age. In this group, the rate of disease was 69 percent lower in 2001 than the base-line rate (59.0 cases per 100,000 vs. 188.0 per 100,000, P