Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study
Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study
复制标题
DOI：
10.3945/ajcn.2009.28500
复制
发表时间：
2010-05-01
影响因子：
7.1
通讯作者：
Sekikawa, Akira
中科院分区：
文献类型：
--
作者：
Choo, Jina;Ueshima, Hirotsugu;Sekikawa, Akira
背景资料：在人群水平上，血清omega-6（n-6）脂肪酸与脂蛋白亚类之间的关系尚不确定。目的：我们旨在研究主要n-6脂肪酸（即亚油酸）与脂蛋白亚类之间的关系。（LA，18：2n-6）和花生四烯酸（AA，20：4 n-6）]和脂蛋白亚类VLDL、LDL和HDL。设计：我们对1098名40-49岁的美国白色、日裔美国人、日本人和韩国男性进行了一项横断面研究。采用毛细管气相色谱法测定血清脂肪酸。通过核磁共振光谱测定脂蛋白亚类。在对年龄、人口、体重指数、吸烟包年、饮酒量、糖尿病、高血压、omega-3（n-3）和反式脂肪酸进行调整后，使用多元线性回归模型作为每种脂肪酸的函数。血清LA与大VLDL呈负相关（β =-0.62，P < 0.001），总LDL（β =-22.08，P < 0.001）、小LDL（β =-31.89，P < 0.001）颗粒浓度和VLDL大小（β =-0.72，P < 0.001）。血清LA与HDL大颗粒浓度（β = 0.21，P < 0.001）和HDL大小（β = 0.03，P < 0.001）呈正相关。AA与大VLDL和大HDL颗粒浓度的关联模式与LA.Conclusions：在人群水平上，较高的血清LA浓度与较低的总LDL颗粒浓度显着相关。较高的血清LA和AA浓度与较低的VLDL大颗粒浓度和较高的HDL大颗粒浓度显著相关。这些关联在所有人群中是一致的。该试验在clinicaltrials.gov上注册为NCT 00069797。美国临床营养杂志2010; 91：1195-203。
Background: The associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain.Objective: We aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL.Design: We conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids.Results: Serum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA.Conclusions: At the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at clinicaltrials.gov as NCT00069797. Am J Clin Nutr 2010; 91: 1195-203.