Gastric adenocarcinoma of the fundic gland type A case report
Gastric adenocarcinoma of the fundic gland type A case report
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DOI：
10.1097/md.0000000000020361
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发表时间：
2020-05-22
期刊：
影响因子：
1.6
通讯作者：
Lin, Xiang-Chun
中科院分区：
文献类型：
--
作者：
Fan, Xue;Yang, Xue-Song;Lin, Xiang-Chun
前言：胃底腺型胃腺癌(GA-FG)是一种新发现的以高分化肿瘤为特征的肿瘤，其病因不明。患者关注：一位60岁的中国男性因腹胀而到本院就诊。诊断：食管胃十二指肠镜(EGD)显示胃大弯有凹陷性病变。活检标本病理诊断为GA-FG(主要细胞占优势类型，GA-FG-CCP)。干预：行鼻内窥镜下黏膜下剥离术。ESD标本病理组织学检查显示，腺癌细胞周围胃底腺型增生。结果：手术效果良好。EGD无复发，术后1年随访无症状。结论：我们报告了一例罕见的凹陷性病变，其致病表达提示胃底腺癌细胞周围的胃底腺型增生。考虑到含氧粘膜的起源，我们认为它可能发展为GA-FG。为了更好地了解这个问题，未来应该监测类似的案例。
Introduction: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described entity that is characterized by well-differentiated neoplasm with unclear etiopathogenesis.Patient concerns: A 60-year-old Chinese man was referred to our hospital for abdominal distension.Diagnosis: Esophagogastroduodenoscopy (EGD) showed a depressed lesion found using in the greater curvature of the stomach. The pathological diagnosis of the biopsy specimens indicated that the tumor was GA-FG (chief cell predominant type, GA-FG-CCP).Interventions: Endoscopic submucosal dissection (ESD) was performed. The histopathological examination of the ESD specimen revealed gastric hyperplasia of the fundic gland type around the adenocarcinoma cells.Outcomes: The surgical outcomes were good. The EGD showed a scar with no recurrence, and no symptoms were observed 1 year postoperatively during the follow-up. Conclusion: We present a rare case of a depressed lesion with a pathogenic expression suggesting gastric hyperplasia of the fundic gland type around the adenocarcinoma cells. Considering the origin of oxyntic mucosa, we consider that it may develop into GA-FG. To understand this issue better, similar cases should be monitored in the future.