Tolerance to anti-pentylenetetrazol effects following chronic diazepam.
Tolerance to anti-pentylenetetrazol effects following chronic diazepam.
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长期地西泮后对抗戊四唑作用的耐受性。
DOI：
10.1016/0014-2999(86)90501-7
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发表时间：
1986
影响因子：
5
通讯作者：
Gallager,DW
中科院分区：
文献类型：
--
作者：
Gonsalves,SF;Gallager,DW
从皮下植入的硅橡胶胶囊中持续释放地西泮可在长达 3 周的时间内对大鼠的戊四氮癫痫发作提供显着的保护。然而，接触地西泮 3 周后的保护程度明显低于接触 1 小时后的保护程度。这些数据表明，持续暴露于持续低水平的地西泮会导致产生部分耐受性，这不足以消除显着的抗惊厥作用。
Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazol seizures in rats for up to 3 weeks. However, the degree of protection seen after 3 weeks of exposure to diazepam was significantly less than after 1 h. These data suggest that continuous exposure to constant low levels of diazepam results in the development of partial tolerance which is not sufficient to eliminate significant anticonvulsant effects.