SPIRAL GANGLION-CELL COUNTS IN AN AGE-GRADED SERIES OF RAT COCHLEAS
SPIRAL GANGLION-CELL COUNTS IN AN AGE-GRADED SERIES OF RAT COCHLEAS
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DOI：
10.1002/cne.901880306
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
FELDMAN, ML
中科院分区：
文献类型：
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作者：
KEITHLEY, EM;FELDMAN, ML
计算各个年龄段的Sprague-Dawley大鼠耳蜗中的螺旋神经节细胞，以评估细胞变性随年龄的程度和位置。在光学显微镜中计数连续截面塑料嵌入的耳蜗的第十一个细胞。 1-2 mo的中间单元格。老动物是15800个细胞。在23个月中，首先看到该数字显着降低（-14％）。老动物。在27-29 mo。神经节细胞的数量减少了20％，而33-34 mo。亏损17％。在整个神经节的长度上发现了损失，下层和顶端的损失最大。在最古老的群体中，这些损失分别为28％和33％。 II型神经节细胞首先显示出27-29个月的数量显着下降。旧组，当看到32％的损失。在33-34 mo中也看到了相同的损失。旧小组。与在神经节的整个长度上丢失的I型细胞不同，II型细胞在基础端的数量并未显着减少，但在中间和顶端区域降低了多达42％。
Spiral ganglion cells in the cochleas of Sprague-Dawley rats in various age groups were counted to assess the extent and location of cell degeneration with age. Cells in every tenth section of serially sectioned plastic embedded cochleas were counted in the light microscope. The median cell number for the 1-2 mo. old animals was 15,800 cells. This number was first seen to be significantly reduced (-14%) in the 23 mo. old animals. At 27-29 mo. the ganglion cell number was reduced by 20%, while at 33-34 mo. there was a 17% loss. Losses were found throughout the length of the ganglion with the greatest losses at the lower basal and apical ends. In the oldest group, these losses amounted to 28% and 33%, respectively. Type II ganglion cells first showed a significant decrease in number in the 27-29 mo. old group, when a 32% loss was seen. The same loss was seen in the 33-34 mo. old group. Unlike the type I cells which are lost throughout the length of the ganglion, type II cells were not significantly reduced in number at the basal end, but decreased by as much as 42% in the middle and apical regions.