LONG-TERM CONSEQUENCE OF EARLY IRON-DEFICIENCY ON DOPAMINERGIC NEUROTRANSMISSION IN RATS
LONG-TERM CONSEQUENCE OF EARLY IRON-DEFICIENCY ON DOPAMINERGIC NEUROTRANSMISSION IN RATS
复制标题
DOI：
10.1016/0736-5748(86)90019-5
复制
发表时间：
1986-01-01
影响因子：
1.8
通讯作者：
YOUDIM, MBH
中科院分区：
文献类型：
--
作者：
BENSHACHAR, D;ASHKENAZI, R;YOUDIM, MBH
大鼠营养性缺铁(ID)导致外周和中枢铁代谢降低。肝脏的这种影响明显大于大脑。虽然脑内非血铁的下降速度慢于血清和肝脏，但这些动物对阿朴吗啡(2 mg/kg)的行为反应和尾状核最大[~3H]螺环酮结合量(Bmax)均显著降低。在幼龄(21日龄)和成年(48日龄)大鼠中，补充铁可以保留ID的这些作用。相反，如果在新生(10日龄)动物中诱发ID，即使在补充铁6周后，脑内非血红铁的减少、对阿朴吗啡和尾状核[~3H]-螺环酮结合的行为反应也不会恢复。然而，这些动物的血清铁、血红蛋白和肝脏铁都是正常的。这些数据表明，早期缺铁对多巴胺能神经传递的发展有深远的影响，因为脑内铁浓度在出生后4-5周达到最大值。这一发现的含义是，儿童缺铁症的流行发生在生命的第一个十年，此时大脑铁积累达到成人观察到的值。与儿童ID相关的深刻认知变化被认为是多巴胺依赖的，而且铁剂疗法并不总是可逆的。
Nutritional iron-deficiency (ID) induced in rats caused a reduction in peripheral as well as central iron metabolism. This effect was markedly greater in the liver than the brain. Although the decrease in the rate of brain non-haem iron was slower than that of serum and liver, significant diminutions of behavioral response to apomorphine (2 mg/kg) and maximum [3H]spiperone binding (Bmax) in caudate nucleus were noted in these animals. These effects of ID can be reserved by iron supplementation in young (21-day-old) and adult (48-day-old) rats. In contrast, if ID is induced in new born (10-day-old) animals, the diminished brain non-haem iron, behavioral response to apomorphine and [3H]-spiperone binding in caudate nucleus will not recover even after 6 weeks of iron supplementation. However, these animals have normal serum iron, haemoglobin and liver iron. These data point to the profound effect early ID can have on the development of dopaminergic neurotransmission, since brain iron concentration increases its maximum in the 4-5 weeks after birth. The implications of the present finding is that the prevalence of ID in children occurs in the first decade of life, when brain iron accumulation reaches values observed in adults. The profound cognitive changes associated with ID in children is thought to be dopamine-dependent and is not always reversible with iron therapy.