Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: effects on anxiety behavior in postpartum and virgin female rats.
Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: effects on anxiety behavior in postpartum and virgin female rats.
复制标题
终纹腹侧床核中的去甲肾上腺素能 α-2 受体调节剂：对产后和处女雌性大鼠焦虑行为的影响。
DOI：
10.1037/a0032776
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发表时间：
2013
影响因子：
1.9
通讯作者：
Lonstein,JosephS
中科院分区：
文献类型：
--
作者：
Smith,CarlD;Piasecki,ChristopherC;Weera,Marcus;Olszewicz,Joshua;Lonstein,JosephS
情绪高反应性可以抑制雌性大鼠和其他动物的母体反应性。通过用α2-自身受体拮抗剂育亨宾或更具选择性的α2-自身受体拮抗剂咪唑克生增加终纹腹侧床核（BSTv）中的去甲肾上腺素释放来破坏产后大鼠的母体行为（Smith等人，2012年）。由于BSTv中的高去甲肾上腺素能活性也会增加焦虑相关的行为，增加的焦虑可能是给予育亨宾或咪唑克生的母鼠的母性中断的基础。为了评估这种可能性，产后大鼠服用育亨宾或咪唑克生后，在高架十字迷宫中评估了焦虑相关行为。进一步评估了α2-自身受体激动剂可乐定（可减少去甲肾上腺素释放）是否会反过来减少母鼠的焦虑。还对不同发情期的处女进行了研究。结果发现，外周或内BSTv育亨宾确实增加产后女性的焦虑相关行为。然而，BSTv输注咪唑克生并没有重现育亨宾的致焦虑作用，外周或BSTv内可乐定也没有减少焦虑。因为育亨宾是一种弱的5 HT 1A受体激动剂，所以其他组的雌性动物接受了5 HT 1A受体激动剂8 OH-DPAT的BSTv输注，但它没有改变它们的焦虑相关行为。最后，去甲肾上腺素和5-羟色胺的组织冲床从BSTv的水平没有产后和diestrous大鼠之间的差异，但5-羟色胺周转率较高的母亲。这些结果表明，BSTv输注育亨宾或咪唑克生后，母体行为受损不能简单地用母鼠焦虑增加来解释，单独的BSTv α2-自身受体调节对产后或动情间期大鼠的焦虑相关行为几乎没有影响。
Emotional hyperreactivity can inhibit maternal responsiveness in female rats and other animals. Maternal behavior in postpartum rats is disrupted by increasing norepinephrine release in the ventral bed nucleus of the stria terminalis (BSTv) with the α2-autoreceptor antagonist, yohimbine, or the more selective α2-autoreceptor antagonist, idazoxan (Smith et al., 2012). Because high noradrenergic activity in the BSTv can also increase anxiety-related behaviors, increased anxiety may underlie the disrupted mothering of dams given yohimbine or idazoxan. To assess this possibility, anxiety-related behaviors in an elevated plus maze were assessed in postpartum rats after administration of yohimbine or idazoxan. It was further assessed if the α2-autoreceptor agonist clonidine (which decreases norepinephrine release) would, conversely, reduce dams’ anxiety. Groups of diestrous virgins were also examined. It was found that peripheral or intra-BSTv yohimbine did increase anxiety-related behavior in postpartum females. However, BSTv infusion of idazoxan did not reproduce yohimbine’s anxiogenic effects and anxiety was not reduced by peripheral or intra-BSTv clonidine. Because yohimbine is a weak 5HT1 A receptor agonist, other groups of females received BSTv infusion of the 5HT1 A receptor agonist 8OH-DPAT, but it did not alter their anxiety-related behavior. Lastly, levels of norepinephrine and serotonin in tissue punches from the BSTv did not differ between postpartum and diestrous rats, but serotonin turnover was higher in mothers. These results suggest that the impaired maternal behavior after BSTv infusion of yohimbine or idazoxan cannot both be readily explained by an increase in dams’ anxiety, and that BSTv α2-autoreceptor modulation alone has little influence on anxiety-related behaviors in postpartum or diestrous rats.