Synthesis, Physicochemical Properties and Biological Evaluation of Aromatic Ester Prodrugs of 1‐(2‘‐Hydroxyethyl)‐2‐ethyl‐3‐hydroxypyridin‐4‐one (CP102): Orally Active Iron Chelators with Clinical Potential
Synthesis, Physicochemical Properties and Biological Evaluation of Aromatic Ester Prodrugs of 1‐(2‘‐Hydroxyethyl)‐2‐ethyl‐3‐hydroxypyridin‐4‐one (CP102): Orally Active Iron Chelators with Clinical Potential
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1-(2-羟乙基)-2-乙基-3-羟基吡啶-4-酮(CP102)芳香酯前药的合成、理化性质和生物学评价：具有临床潜力的口服活性铁螯合剂
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
R. Hider
中科院分区：
文献类型：
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作者：
Z. Liu;D. Liu;Shu L. Lu;R. Hider
报道了7种1-（2′-羟乙基）-2-乙基-3-羟基吡啶-4-酮芳香酯衍生物的合成。这些酯前药被设计为将铁螯合剂靶向肝脏，主要的铁储存器官。原则上，这应该提高螯合功效并使毒性最小化。
The synthesis of seven aromatic ester derivatives of 1‐(2′‐hydroxyethyl)‐2‐ethyl‐3‐hydro‐xypyridin‐4‐one is described. These ester prodrugs have been designed to target iron chelators to the liver, the major iron storage organ. In principle this should improve chelation efficacy and minimize toxicity.
羟基吡啶-4-一铁螯合剂对小鼠的相对口服功效和急性毒性。
影响因子：
20.3
作者：
Porter,JB;Morgan,J;Hoyes,KP;Burke,LC;Huehns,ER;Hider,RC
通讯作者：
Hider,RC