HYDROLYSIS OF PERMETHRIN, A PYRETHROID INSECTICIDE, BY RAINBOW-TROUT AND MOUSE-TISSUES INVITRO - A COMPARATIVE-STUDY
HYDROLYSIS OF PERMETHRIN, A PYRETHROID INSECTICIDE, BY RAINBOW-TROUT AND MOUSE-TISSUES INVITRO - A COMPARATIVE-STUDY
复制标题
DOI：
10.1016/0041-008x(91)90222-z
复制
发表时间：
1981-01-01
影响因子：
3.8
通讯作者：
LECH, JJ
中科院分区：
文献类型：
--
作者：
GLICKMAN, AH;LECH, JJ
Permethrin, a pyrethroid insecticide, is highly toxic to fish relative to its toxicity to mammals and the role of permethrin metabolism in this differential toxicity has not been investigated. A previous study showed that little hydrolysis of permethrin occurred in vivo in rainbow trout in contrast to mammals where ester hydrolysis was a major detoxification reaction. The rates of permethrin hydrolysis in rainbow trout and mouse tissues in vitro were estimated. Mouse liver, kidney and plasma incubated at 37.degree. C, hydrolyzed trans-[14C]permethrin .apprx. 166, 38 and 59 times faster, respectively, than the same rainbow trout tissues incubated at 12.degree. C. At an incubation temperature of 37.degree. C trout liver microsomes hydrolyzed trans-permethrin .apprx. 45 times slower than mouse liver microsomes. When the total capacity of trout and mouse tissues to hydrolyze trans-permethrin was compared on a whole body basis mice hydrolyzed trans-permethrin 184 times faster than rainbow trout. Rainbow trout tissues had a lower capacity than mouse tissues to hydrolyze permethrin and this may explain the relative absence of permethrin hydrolysis products in permethrin-exposed rainbow trout. It was impossible that the high toxicity of permethrin to rainbow trout was related to a low capacity to hydrolyze permethrin.
