Family study of subthreshold depressive symptoms: risk factor for MDD?
Family study of subthreshold depressive symptoms: risk factor for MDD?
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DOI：
10.1016/s0165-0327(02)00106-4
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发表时间：
2003-11-01
影响因子：
6.6
通讯作者：
Rohde, P
中科院分区：
文献类型：
--
作者：
Lewinsohn, PM;Klein, DN;Rohde, P
背景：来自大量社区年轻人及其一级亲属样本的家庭研究数据被用来检验关于阈下抑郁（SubD）和重度抑郁症（MDD）之间关系的三个问题：（a）患有 SubD 的先证者亲属中 MDD 发生率是否升高？ (b) SubD 是否聚集在患有 MDD 和 SubD 的先证者家族中？ (c) SubD 和家族性精神病理学之间的关系是 MDD 所特有的吗？方法：总共 941 名先证者在青春期和 24 岁时接受了两次评估。获得了 840 名先证者的 2750 名一级亲属的直接和知情信息。结果：SubD先证者亲属中MDD发生率（24.3%）显着低于MDD先证者亲属（31.9%），但显着高于无情绪障碍史先证者亲属（NMD；20.2%）。 MDD、SubD 和 NMD 先证者的亲属在 SubD 发生率方面没有差异（分别为 9.0%、9.4% 和 9.0%）。 SubD先证者精神病理学的家族聚集是MDD所特有的。局限性：主要的局限性可能是 SubD 类别缺乏标准化的定义和评估程序。此外，样本量虽然很大，但可能不足以检测较小的关联或性别的调节作用。结论：结果数据支持这样的观点，即 SubD 在 MDD 的连续体中占据较温和的位置。 (C) 2002 Elsevier B.V. 保留所有权利。
Background: Family study data from a large community sample of young adults and their first-degree relatives were used to examine three questions regarding the relation between subthreshold depression (SubD) and major depressive disorder (MDD): (a) is there an elevated rate of MDD in the relatives of probands with SubD? (b) does SubD aggregate in the families of probands with MDD and SubD? (c) is the relationship between SubD and familial psychopathology specific to MDD? Methods: A total of 941 probands were assessed twice during adolescence and then at age 24. Direct and informant information was obtained on 2750 first-degree relatives of 840 probands. Results: The rate of MDD in the relatives of probands with SubD (24.3%) was significantly lower than the relatives of probands with MDD (31.9%) but was significantly higher than the relatives of probands with no history of mood disorder (NMD; 20.2%). Relatives of MDD, SubD and NMD probands did not differ on rates of SubD (9.0, 9.4 and 9.0%, respectively). Familial aggregation of psychopathology in SubD probands was specific to MDD. Limitations: The primary limitation may be the absence of a standardized definition and assessment procedure for the SubD category. In addition, the sample size, although large, may have been inadequate to detect smaller associations or the moderating effects of sex. Conclusion: The results data support the view that SubD occupies a milder position on a continuum with MDD. (C) 2002 Elsevier B.V. All rights reserved.