Retention of lepirudin at the tip of a silicone catheter: a better catheter flush solution?
Retention of lepirudin at the tip of a silicone catheter: a better catheter flush solution?
复制标题
将来匹卢定保留在硅胶导管尖端：更好的导管冲洗溶液？
DOI：
10.1007/s00520-004-0592-7
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Inkellis,Elizabeth
中科院分区：
文献类型：
--
作者：
Horne3rd,McDonaldK;Inkellis,Elizabeth
Because central venous catheters often become blocked by clot at their tip despite heparin flushes, a more effective anticoagulant is needed. We hypothesize that lepirudin, a recently introduced protein anticoagulant, might be more effective than heparin because of its tendency to adsorb to silicone, a commonly used catheter material. We preliminarily tested this hypothesis in vitro by measuring residual lepirudin and heparin activity at the tip of a catheter that had been submerged in a flowing stream of water for various periods of time. We observed that lepirudin is less readily removed than heparin from the catheter by fluid washing over it. This “slow-release” property of lepirudin might provide prolonged protection against clot formation at the catheter tip. A clinical trial will be necessary, however, to determine whether this property translates into significant improvement in catheter function.
