A computational and cellular solids approach to the stiffness-based design of bone scaffolds.
A computational and cellular solids approach to the stiffness-based design of bone scaffolds.
复制标题
用于基于刚度的骨支架设计的计算和细胞实体方法。
DOI：
10.1115/1.4004994
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
A. J. W. Johnson
中科院分区：
文献类型：
--
作者：
Julián A. Norato;A. J. W. Johnson
我们推导出一个细胞固体的方法来设计骨支架的刚度和孔径。具体来说，我们专注于由羟基磷灰石棒的堆叠、交替、正交层制成的支架，例如通过微型机器人沉积获得的那些，并且旨在确定获得指定弹性模量和孔径所需的棒直径、间距和重叠。为了验证和校准细胞固体模型，我们采用有限元模型，并通过数值均匀化确定有效支架模量。为了进行有效的，自动执行的数值研究，我们采用了几何投影方法，使对应于不同的支架尺寸的分析可以在一个固定的，不符合网格。基于所开发的模型，我们提供设计图表，以帮助选择杆直径，间距和重叠，用于机器人沉积，以达到所需的弹性模量和孔径。
We derive a cellular solids approach to the design of bone scaffolds for stiffness and pore size. Specifically, we focus on scaffolds made of stacked, alternating, orthogonal layers of hydroxyapatite rods, such as those obtained via micro-robotic deposition, and aim to determine the rod diameter, spacing and overlap required to obtain specified elastic moduli and pore size. To validate and calibrate the cellular solids model, we employ a finite element model and determine the effective scaffold moduli via numerical homogenization. In order to perform an efficient, automated execution of the numerical studies, we employ a geometry projection method so that analyses corresponding to different scaffold dimensions can be performed on a fixed, non-conforming mesh. Based on the developed model, we provide design charts to aid in the selection of rod diameter, spacing and overlap to be used in the robotic deposition to attain desired elastic moduli and pore size.