Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing.
Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing.
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DOI：
10.1155/2010/790234
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发表时间：
2010
影响因子：
1.5
通讯作者：
Kathju S
中科院分区：
文献类型：
--
作者：
Satish L;Kathju S
本文的目的是比较和对比离散生物学区分胎儿伤口修复与成人的对应。哺乳动物胎儿的表皮伤口愈合与成人皮肤的伤口愈合有本质的不同。成人（出生后）皮肤伤口愈合是一个复杂而精心策划的过程，由伴随的炎症刺激，导致伤口闭合并形成疤痕。相比之下，胎儿伤口修复的炎症最小，再上皮化更快，没有疤痕的积累。尽管对无疤痕愈合的研究在几十年前就开始了，但驱动再生胎儿愈合过程的关键分子机制仍然不确定。了解再生愈合过程中的分子和细胞事件可能会提供线索，使我们有一天能够调节成人伤口愈合，从而减少疤痕。
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.