Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.
Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.
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DOI：
10.2174/138955751513150923094709
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shen H
中科院分区：
文献类型：
--
作者：
Khalid A;Wolfram J;Ferrari I;Mu C;Mai J;Yang Z;Zhao Y;Ferrari M;Ma X;Shen H
癌症患者死亡的最常见原因是转移。因此，目前正在研究各种治疗策略，以开发能够靶向和抑制促进肿瘤侵袭的因子的有效药物。相当多的重点放在研究癌症作为一个炎症过程中进行的动态微环境。事实上，肿瘤微环境已经被认为对转移有相当大的贡献。例如，由肿瘤微环境中的细胞产生的趋化因子C-C基序配体5（CCL 5）已被确定为转移性疾病的重要贡献者。最近，CCL 5在乳腺癌侵袭中的作用已被广泛研究。本文综述了该趋化因子的最新研究进展，包括增加CCL 5产生的条件以及该信号通路介导的作用。此外，还讨论了CCL 5及其受体趋化因子C-C基序受体5（CCR 5）作为治疗和/或预防乳腺癌转移的靶点的潜在用途。
The most common cause of mortality in cancer patients is metastasis. Therefore, a variety of therapeutic strategies are currently under investigation to develop effective drugs that can target and inhibit factors that promote tumor invasion. Considerable emphasis has been placed on studying cancer as an inflammatory process that proceeds in a dynamic microenvironment. In fact, the tumor microenvironment has been implicated to contribute considerably to metastasis. For instance, chemokine C-C motif ligand 5 (CCL5) produced by cells in the tumor microenvironment has been established as an important contributor to metastatic disease. Recently, the role of CCL5 in breast cancer invasion has been extensively studied. This review summarizes the recent developments in regards to this chemokine, including the conditions that increase the generation of CCL5 and the effects mediated by this signaling pathway. Moreover, the potential use of CCL5 and its receptor chemokine C-C motif receptor 5 (CCR5) as a target for treating and/or preventing breast cancer metastasis is also discussed.