Physical and molecular properties of agrochemicals: An analysis of screen inputs, hits, leads, and products
Physical and molecular properties of agrochemicals: An analysis of screen inputs, hits, leads, and products
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DOI：
10.2533/000942903777678641
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发表时间：
2003-01-01
期刊：
影响因子：
1.2
通讯作者：
Delaney, JS
中科院分区：
文献类型：
--
作者：
Clarke, ED;Delaney, JS
这项工作提供了一个全面的概述农业化学性质的方式，他们改变过程中的进展，从屏幕击中产品和他们的限制，在现代商业产品。大多数除草剂和杀真菌剂很容易满足Lipinski的“五规则”标准的药物样化合物与许多满足更严格的限制报告的药物线索。
This work provides a comprehensive overview of agrochemical properties in terms of the way they change during progression from screen hit to product and in terms of their limits as expressed in modern commercial products. Most herbicides and fungicides readily meet the Lipinski 'rule of five' criteria for drug-like compounds with many meeting the more constrained limits reported for pharmaceutical leads.