ACTION OF VINCA ALKALOIDES ON CALCIUM MOVEMENTS THROUGH MITOCHONDRIAL-MEMBRANE
ACTION OF VINCA ALKALOIDES ON CALCIUM MOVEMENTS THROUGH MITOCHONDRIAL-MEMBRANE
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DOI：
10.1016/0031-6989(86)90147-5
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发表时间：
1986-06-01
期刊：
影响因子：
--
通讯作者：
AIME, C
中科院分区：
文献类型：
--
作者：
CHANTAL, T;NANCY, F;AIME, C
抗有丝分裂药物长春花碱和长春新碱部分抵消了钙离子载体和 Ca2+ 对线粒体的解偶联作用。呼吸控制的部分恢复主要是由于状态4中氧化速率的作用。以同样的方式，P/O比部分恢复。此外，长春花生物碱会降低需氧过程中钙的吸收率及其进入线粒体的量，并减缓钙的流出。这些结果可以通过长春花生物碱对线粒体膜的非特异性作用来解释，并可能导致细胞质 Ca2+ 浓度的变化。
The antimitotic drugs Vinblastine and Vincristine partially counteract the decoupling effect of both calcium ionophore and Ca2+ on mitochondria. The partial restoration of respiratory control is mainly due to an action on oxidative rate in state 4. In the same manner the P/O ratio is partially restorated. Moreover Vinca alkaloides decrease both the calcium uptake rate and its amount into mitochondria during aerobiosis and slacken the calcium efflux. These results may be explained by a non specific effect of Vinca alkaloides on mitochondrial membrane and might lead to a change in cytoplasmic Ca2+ concentration.