Erythromycin and clindamycin resistance and telithromycin susceptibility in Streptococcus agalactiae
Erythromycin and clindamycin resistance and telithromycin susceptibility in Streptococcus agalactiae
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DOI：
10.1128/aac.47.3.1112-1114.2003
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发表时间：
2003-03-01
影响因子：
4.9
通讯作者：
Picazo, JJ
中科院分区：
文献类型：
--
作者：
Betriu, C;Culebras, E;Picazo, JJ
我院分离的无乳链球菌菌株对红霉素和克林霉素的耐药率由1993年的4.2%和0.8%分别上升到2001年的17.4%和12.1%。红霉素耐药主要是由于Erm(B)甲基化酶的存在，其中3.8%的菌株检出M表型。泰利霉素对红霉素耐药菌株非常有效，无论其大环内酯类耐药机制如何。
The rates of resistance to erythromycin and clindamycin among Streptococcus agalactiae strains isolated in our hospital increased from 4.2 and 0.8% in 1993 to 17.4 and 12.1%, respectively, in 2001. Erythromycin resistance was mainly due to the presence of an Erm(B) methylase, while the M phenotype was detected in 3.8% of the strains. Telithromycin was very active against erythromycin-resistant strains, irrespective of their mechanisms of macrolide resistance.