Cancer and radiation therapy: current advances and future directions.
Cancer and radiation therapy: current advances and future directions.
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DOI：
10.7150/ijms.3635
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发表时间：
2012
影响因子：
3.6
通讯作者：
Yeoh KW
中科院分区：
文献类型：
--
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
近年来，在理解癌症发展和治疗的拟议标志方面取得了显着进展。然而，随着其发病率的增加，癌症的临床管理仍然是21世纪世纪的挑战。治疗方式包括放射疗法、手术、化疗、免疫疗法和激素疗法。放射治疗仍然是癌症治疗的一个重要组成部分，大约50%的癌症患者在疾病过程中接受放射治疗;它有助于40%的癌症治愈治疗。放射治疗的主要目的是剥夺癌细胞的增殖（细胞分裂）潜力。自玛丽·居里（Marie Curie）因镭研究第二次获得诺贝尔奖以来，庆祝一个世纪的进步，2011年被指定为英国放射治疗年。在过去的100年里，放射治疗技术的不断进步和在理解癌细胞对放射反应的生物学方面取得的进展将奋进提高癌症患者的生存率并减少治疗副作用。本文就放射治疗的原理、应用、进展及其生物学终点作一综述。
In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. However with its increasing incidence, the clinical management of cancer continues to be a challenge for the 21st century. Treatment modalities comprise of radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. Radiation therapy remains an important component of cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during their course of illness; it contributes towards 40% of curative treatment for cancer. The main goal of radiation therapy is to deprive cancer cells of their multiplication (cell division) potential. Celebrating a century of advances since Marie Curie won her second Nobel Prize for her research into radium, 2011 has been designated the Year of Radiation therapy in the UK. Over the last 100 years, ongoing advances in the techniques of radiation treatment and progress made in understanding the biology of cancer cell responses to radiation will endeavor to increase the survival and reduce treatment side effects for cancer patients. In this review, principles, application and advances in radiation therapy with their biological end points are discussed.
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影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
癌症中的线粒体：在生与死的十字路口。
影响因子：
--
作者：
Fogg VC;Lanning NJ;Mackeigan JP
通讯作者：
Mackeigan JP
影响因子：
78.5
作者：
Bernier, J;Hall, EJ;Giaccia, A
通讯作者：
Giaccia, A
DOI：
10.1016/s0360-3016(02)02884-5
发表时间：
2002-08-01
影响因子：
7
作者：
Jaffray, DA;Siewerdsen, JH;Martinez, AA
通讯作者：
Martinez, AA
DOI：
10.1016/s0360-3016(00)01482-6
发表时间：
2001-02-01
影响因子：
7
作者：
Brown, JM
通讯作者：
Brown, JM